RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Pulmonary arterial hypertension (PAH) is a devastating disease that involves pulmonary
vasoconstriction, small vessel obliteration, large vessel thickening and obstruction, and …

Recent years have witnessed incredible growth in RNA therapeutics, which has benefited
significantly from decades of research on lipid nanoparticles, specifically its key component …

Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the
particular administration route and type of drug. Here we report the design of LNPs for the …

Endosomal escape remains a fundamental barrier hindering the advancement of nucleic
acid therapeutics. Taking inspiration from natural phospholipids that comprise biological …

Nowadays, cancer is one of the most prominent issues related to human health since it
causes more than one-tenth of death cases throughout the world. On the other hand, routine …

Abstract mRNA vaccines have become a promising platform for cancer immunotherapy.
During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor …

Faced with the challenges posed by infectious diseases and cancer, nucleic acid vaccines
present excellent prospects in clinical applications. Compared with traditional vaccines …

Cancer has reached pandemic dimensions in the whole world. Although current medicine
offers multiple treatment options against cancer, novel therapeutic strategies are needed …

The field of nanotechnology and personalised medicine is undergoing drastic changes in
the approach and efficiency of experimentation. The COVID-19 pandemic has spiralled into …