Genes involved in the production of pulmonary surfactant are crucial for the development
and maintenance of healthy lungs. Germline mutations in surfactant-related genes cause a …

Surfactant, which was first identified in the 1920s, is pivotal to lower the surface tension in
alveoli of the lungs and helps to lower the work of breathing and prevents atelectasis …

Acute inflammatory exacerbations (AIE) represent precipitous deteriorations of a number of
chronic lung conditions, including pulmonary fibrosis (PF), chronic obstructive pulmonary …

Genetic mechanisms are now recognized as rare causes of neonatal lung disease. Genes
potentially responsible for neonatal lung disease include those encoding proteins important …

Interventions: Tracheal intubation was performed with invasive ventilator-assisted breathing,
pulmonary surfactant was administered. Supportive treatment for liver protection and …

Abstract Surfactant protein C (SP-C) is one of four surfactant proteins produced by type II
pneumocytes. Mutations in surfactant protein A are strongly associated with development of …

Dysfunction of type II alveolar cells due to deficiency in the lipid transporter protein, ATP-
binding cassette subfamily A member3 (ABCA-3), can cause lung disease in children. The …

Background Mutation in the surfactant protein C gene (SFTPC) is a cause of interstitial lung
disease (ILD). Our objective was to investigate the clinical characteristics, outcome and …