Neurofibromatosis type 2 (NF2) and the implications for vestibular schwannoma and meningioma pathogenesis
Patients diagnosed with neurofibromatosis type 2 (NF2) are extremely likely to develop
meningiomas, in addition to vestibular schwannomas. Meningiomas are a common primary …
meningiomas, in addition to vestibular schwannomas. Meningiomas are a common primary …
[HTML][HTML] Meningioma genomics: a therapeutic challenge for clinicians
C Moussalem, E Massaad, GB Minassian… - Journal of integrative …, 2021 - imrpress.com
Meningiomas are amongst the most commonly encountered intracranial tumors. The
majority of these tumors arise intracranially, and the remaining incidents occur along the …
majority of these tumors arise intracranially, and the remaining incidents occur along the …
Associations of pathological diagnosis and genetic abnormalities in meningiomas with the embryological origins of the meninges
Certain driver mutations and pathological diagnoses are associated with the anatomical site
of meningioma, based on which the meninges have different embryological origins. We …
of meningioma, based on which the meninges have different embryological origins. We …
A prognostic gene-expression signature and risk score for meningioma recurrence after resection
BACKGROUND Prognostic markers for meningioma are needed to risk-stratify patients and
guide postoperative surveillance and adjuvant therapy. OBJECTIVE To identify a prognostic …
guide postoperative surveillance and adjuvant therapy. OBJECTIVE To identify a prognostic …
Sarcomatous meningioma: diagnostic pitfalls and the utility of molecular testing
CHG Lucas, P Devine, DA Solomon… - … of Neuropathology & …, 2021 - academic.oup.com
Anaplastic meningiomas can have a sarcomatous appearance on histology but true
sarcomatous (metaplastic) differentiation is rare. These tumors follow an aggressive clinical …
sarcomatous (metaplastic) differentiation is rare. These tumors follow an aggressive clinical …
Comprehensive proteomic analysis reveals distinct functional modules associated with skull base and supratentorial meningiomas and perturbations in collagen …
S Mukherjee, D Biswas, S Epari, P Shetty, A Moiyadi… - Journal of …, 2021 - Elsevier
Meningiomas are brain tumors that originate from the meninges and has been primarily
classified into three grades by the current WHO guidelines. Although widely prevalent and …
classified into three grades by the current WHO guidelines. Although widely prevalent and …
Whole-exome sequencing reveals recurrent but heterogeneous mutational profiles in sporadic WHO Grade 1 meningiomas
M González-Tablas, C Prieto, D Arandia… - Frontiers in …, 2021 - frontiersin.org
Human WHO grade 1 meningiomas are generally considered benign tumors; despite this,
they account for≈ 50% of all recurrent meningiomas. Currently, limited data exist about the …
they account for≈ 50% of all recurrent meningiomas. Currently, limited data exist about the …
GAB1 overexpression identifies Hedgehog‐activated anterior skull base meningiomas
J Boetto, J Lerond, M Peyre, S Tran… - Neuropathology and …, 2021 - Wiley Online Library
Aims Mutations activating the hedgehog (Hh) signalling pathway have been described in
anterior skull base meningiomas, raising hope for the use of targeted therapies. However …
anterior skull base meningiomas, raising hope for the use of targeted therapies. However …
[HTML][HTML] Alteration of FOXM1 expression and macrophage polarization in refractory meningiomas during long-term follow-up
J Takei, T Tanaka, A Teshigawara… - Translational Cancer …, 2021 - ncbi.nlm.nih.gov
Malignant progression of grade I meningioma with a long latency period is rare. We
experienced grade II/III meningiomas with refractoriness and recurrence from grade I …
experienced grade II/III meningiomas with refractoriness and recurrence from grade I …
Receptor tyrosine kinases as candidate prognostic biomarkers and therapeutic targets in meningioma
Meningioma (MGM) is the most common type of intracranial tumor in adults. The validation
of novel prognostic biomarkers to better inform tumor stratification and clinical prognosis is …
of novel prognostic biomarkers to better inform tumor stratification and clinical prognosis is …