Neurofibromatosis type 2 (NF2) and the implications for vestibular schwannoma and meningioma pathogenesis

S Bachir, S Shah, S Shapiro, A Koehler… - International journal of …, 2021 - mdpi.com
Patients diagnosed with neurofibromatosis type 2 (NF2) are extremely likely to develop
meningiomas, in addition to vestibular schwannomas. Meningiomas are a common primary …

[HTML][HTML] Meningioma genomics: a therapeutic challenge for clinicians

C Moussalem, E Massaad, GB Minassian… - Journal of integrative …, 2021 - imrpress.com
Meningiomas are amongst the most commonly encountered intracranial tumors. The
majority of these tumors arise intracranially, and the remaining incidents occur along the …

Associations of pathological diagnosis and genetic abnormalities in meningiomas with the embryological origins of the meninges

A Okano, S Miyawaki, H Hongo, S Dofuku… - Scientific Reports, 2021 - nature.com
Certain driver mutations and pathological diagnoses are associated with the anatomical site
of meningioma, based on which the meninges have different embryological origins. We …

A prognostic gene-expression signature and risk score for meningioma recurrence after resection

WC Chen, HN Vasudevan, A Choudhury… - …, 2021 - journals.lww.com
BACKGROUND Prognostic markers for meningioma are needed to risk-stratify patients and
guide postoperative surveillance and adjuvant therapy. OBJECTIVE To identify a prognostic …

Sarcomatous meningioma: diagnostic pitfalls and the utility of molecular testing

CHG Lucas, P Devine, DA Solomon… - … of Neuropathology & …, 2021 - academic.oup.com
Anaplastic meningiomas can have a sarcomatous appearance on histology but true
sarcomatous (metaplastic) differentiation is rare. These tumors follow an aggressive clinical …

Comprehensive proteomic analysis reveals distinct functional modules associated with skull base and supratentorial meningiomas and perturbations in collagen …

S Mukherjee, D Biswas, S Epari, P Shetty, A Moiyadi… - Journal of …, 2021 - Elsevier
Meningiomas are brain tumors that originate from the meninges and has been primarily
classified into three grades by the current WHO guidelines. Although widely prevalent and …

Whole-exome sequencing reveals recurrent but heterogeneous mutational profiles in sporadic WHO Grade 1 meningiomas

M González-Tablas, C Prieto, D Arandia… - Frontiers in …, 2021 - frontiersin.org
Human WHO grade 1 meningiomas are generally considered benign tumors; despite this,
they account for≈ 50% of all recurrent meningiomas. Currently, limited data exist about the …

GAB1 overexpression identifies Hedgehog‐activated anterior skull base meningiomas

J Boetto, J Lerond, M Peyre, S Tran… - Neuropathology and …, 2021 - Wiley Online Library
Aims Mutations activating the hedgehog (Hh) signalling pathway have been described in
anterior skull base meningiomas, raising hope for the use of targeted therapies. However …

[HTML][HTML] Alteration of FOXM1 expression and macrophage polarization in refractory meningiomas during long-term follow-up

J Takei, T Tanaka, A Teshigawara… - Translational Cancer …, 2021 - ncbi.nlm.nih.gov
Malignant progression of grade I meningioma with a long latency period is rare. We
experienced grade II/III meningiomas with refractoriness and recurrence from grade I …

Receptor tyrosine kinases as candidate prognostic biomarkers and therapeutic targets in meningioma

R Roesler, BK Souza, GR Isolan - International Journal of Molecular …, 2021 - mdpi.com
Meningioma (MGM) is the most common type of intracranial tumor in adults. The validation
of novel prognostic biomarkers to better inform tumor stratification and clinical prognosis is …