RNA-seq, including single cell RNA-seq (scRNA-seq), is plagued by insufficient sensitivity
and lack of precision. As a result, the full potential of (sc) RNA-seq is limited. Major factors in …

Studies evaluating neuroimaging, genetically predicted gene expression, and pre-clinical
genetic models of PTSD, have identified PTSD-related abnormalities in the prefrontal cortex …

Gene expression and translation have been extensively studied in human post-mortem
brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) …

Abstract Background Both RNA-Seq and sample freeze-thaw are ubiquitous. However,
knowledge about the impact of freeze-thaw on downstream analyses is limited. The lack of …

Background RNA sequencing (RNA-seq) is a common and widespread biological assay,
and an increasing amount of data is generated with it. In practice, there are a large number …

Problem Current scientific guidelines recommend collecting placental specimens within two
hours of delivery for gene expression analysis. However, collecting samples in a narrow …

RNA integrity numbers (RINs) are a standardized method for semi-quantification of RNA
degradation, and are used in quality control prior to transcriptional profiling analysis. Recent …

Schizophrenia is a serious, complex psychiatric illness that affects around 1% of people
globally, costing billions of dollars and negatively impacting quality of life. It's exact causes …

While the role of genomic risk for schizophrenia on brain gene co-expression networks has
been described, the patterns of its manifestations are varied and complex. To acquire a …

Transcriptional profiling (TP) is a common tool to determine RNA expression levels. It allows
for thousands of genes to be analyzed simultaneously, and determines differences in gene …