Type 2 diabetes (T2D) is a growing cause of poor health, psychosocial burden, and
economic costs worldwide. The pancreatic β-cell is a cornerstone of metabolic physiology …

In response to disturbed mitochondrial gene expression and protein synthesis, an adaptive
transcriptional response sharing a signature of the integrated stress response (ISR) is …

Immature myeloid cells at varied stages of differentiation, known as myeloid-derived
suppressor cells (MDSC), are present in virtually all cancer patients. MDSC are profoundly …

Abstract C/EBP homologous protein (CHOP), a 29 kDa cellular protein, plays a role in
regulating tumor proliferation, differentiation, metabolism, cell death, and in tumor resistance …

Protein kinases are intracellular signaling enzymes that catalyze the phosphorylation of
specific residues in their target substrate proteins. They play important role for regulation of …

Herpesvirus gene expression is dynamic and complex, with distinct complements of viral
genes expressed at specific times in different infection contexts. These patterns of viral gene …