The incidence of metabolic disorders, as well as of neurodegenerative diseases—mainly the
sporadic forms of Alzheimer's and Parkinson's disease—are increasing worldwide. Notably …

Background: Familial hypercholesterolemia (FH) lead to significant adverse effects in
coronary arteries. Mipomersen is a second-generation antisense oligonucleotide that …

Objectives This study aimed at investigating the additional contribution of coronary artery
calcium (CAC) score to SAFEHEART (Spanish Familial Hypercholesterolemia Cohort Study) …

Background and aims Familial hypercholesterolemia (FH) is characterized by high LDL-
cholesterol (LDL-C) and early atherosclerotic cardiovascular disease (ASCVD). With a lipid …

Introduction: Familial hypercholesterolemia (FH) is a highly prevalent condition,
predisposing individuals to premature cardiovascular disease and with a genetic basis more …

Although the incidence of acute myocardial infarction (AMI) has been decreasing in the
elderly, it has been increasing in the young, especially in Japan. A social impact of AMI …

Background There is a paucity of contemporary data regarding the outcomes of acute
myocardial infarction among patients with familial hypercholesteremia. Methods We queried …

Hypercholesterolemia has previously been induced in the mouse by a single intravenous
injection of adeno-associated virus (AAV)-based vector harboring gain-of-function pro …

Familial Hypercholesterolemia (FH) is an autosomal, dominant, inherited disorder
characterized by severely elevated LDL-cholesterol (LDL-C) levels with high risk for …

Prevention of premature disease and death from cardiovascular complications of
atherosclerosis is an important goal for public health, and the early identification of …