Vitamin B12 (cobalamin) is an essential cofactor for two metabolic pathways. It is obtained
principally from food of animal origin. Cobalamin becomes bioavailable through a series of …

Abstract Background The Treatable ID App was created in 2012 as digital tool to improve
early recognition and intervention for treatable inherited metabolic disorders (IMDs) …

Triple-negative breast cancer (TNBC) is characterized by a more aggressive clinical course
with extensive inter-and intra-tumour heterogeneity. Combination of single-cell and bulk …

ATP-binding cassette (ABC) transporters constitute one of the largest superfamilies of
conserved proteins from bacteria to mammals. In humans, three members of this family are …

Conspectus Metals are partners for an estimated one-third of the proteome and vary in
complexity from mononuclear centers to organometallic cofactors. Vitamin B12 or cobalamin …

Lysosomes are degradative organelles in eukaryotic cells mediating the hydrolytic
catabolism of various macromolecules to small basic building blocks. These low‐molecular …

Vitamin B12 (VitB12) is a naturally occurring compound produced by microorganisms and
an essential nutrient for humans. Several papers highlight the role of VitB12 deficiency in …

Disorders of intracellular cobalamin metabolism have a variable phenotype and age of
onset that are influenced by the severity and location within the pathway of the defect. The …

Porcine vertebral and teat numbers are variable and important economic traits in pig
production. However, the quantitative trait loci (QTL) and candidate genes for both of these …

Vitamin deficiency is well known to contribute to disease development in both humans and
other animals. Nonetheless, truly understanding the role of vitamins in human biology …