The Paf1 complex: a keystone of nuclear regulation operating at the interface of transcription and chromatin
The regulation of transcription by RNA polymerase II is closely intertwined with the
regulation of chromatin structure. A host of proteins required for the disassembly …
regulation of chromatin structure. A host of proteins required for the disassembly …
Ready, SET, Go: Post-translational regulation of the histone lysine methylation network in budding yeast
RJ Separovich, MR Wilkins - Journal of Biological Chemistry, 2021 - ASBMB
Histone lysine methylation is a key epigenetic modification that regulates eukaryotic
transcription. Here, we comprehensively review the function and regulation of the histone …
transcription. Here, we comprehensively review the function and regulation of the histone …
Biochemical insights into Paf1 complex–induced stimulation of Rad6/Bre1-mediated H2B monoubiquitination
F Chen, B Liu, L Guo, X Ge, W Feng… - Proceedings of the …, 2021 - National Acad Sciences
The highly conserved multifunctional polymerase-associated factor 1 (Paf1) complex
(PAF1C), composed of five core subunits Paf1, Leo1, Ctr9, Cdc73, and Rtf1, participates in …
(PAF1C), composed of five core subunits Paf1, Leo1, Ctr9, Cdc73, and Rtf1, participates in …
Opposing functions of the Hda1 complex and histone H2B mono-ubiquitylation in regulating cryptic transcription in Saccharomyces cerevisiae
MK Shirra, RA Kocik, MA Ellison, KM Arndt - G3, 2021 - academic.oup.com
Maintenance of chromatin structure under the disruptive force of transcription requires
cooperation among numerous regulatory factors. Histone post-translational modifications …
cooperation among numerous regulatory factors. Histone post-translational modifications …
Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters
BB Lee, H Woo, MK Lee, SJ Youn, S Lee… - Nucleic acids …, 2021 - academic.oup.com
Abstract During RNA polymerase II (RNA Pol II) transcription, the chromatin structure
undergoes dynamic changes, including opening and closing of the nucleosome to enhance …
undergoes dynamic changes, including opening and closing of the nucleosome to enhance …
Rho termination factor: one ring to bind them all
ND Sunday, D Svetlov, I Artsimovitch - 2021 - books.rsc.org
In the classical model of transcription, RNA polymerase (RNAP) initiates at a promoter and
stops at a terminator, making RNAs that are useful for the cell under current physiological …
stops at a terminator, making RNAs that are useful for the cell under current physiological …
Dynamics of transcription elongation are finely tuned by dozens of regulatory factors
Understanding the complex network and dynamics that regulate transcription elongation
requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of …
requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of …
PAF1 complex and MYC couple transcription elongation with double-strand break repair
T Endres - 2021 - opus.bibliothek.uni-wuerzburg.de
The oncogene MYC is deregulated and overexpressed in a high variety of human cancers
and is considered an important driver in tumorigenesis. The MYC protein binds to virtually all …
and is considered an important driver in tumorigenesis. The MYC protein binds to virtually all …