Immunoglobulins (Igs) are complex glycoproteins that play critical functions in innate and
adaptive immunity of all jawed vertebrates. Given the unique characteristics of mucosal …

There has been a longstanding question of whether affinity maturation occurs in ectotherms,
and if it does, where in tissues this happens. Although cold-blooded vertebrates …

The rules underlying the structure of antigen receptor repertoires are not yet fully defined,
despite their enormous importance for the understanding of adaptive immunity. With current …

Background Plasma cells are terminally differentiated B cells that produce large quantities of
immunoglobulin (also called antibody; Fig. 1), which serves as the body's defense against …

High-throughput sequencing technologies brought a renewed interest for immune
repertoires. Fish Ab and B cell repertoires are no exception, and their comprehensive …

The high-throughput analysis of antibody responses with regards to their genotypic and
phenotypic features not only provides detailed insights into their basic biology, but can also …

Ataxia-Telangiectasia is a life-limiting, neurodegenerative disorder, phenotypically
characterised by ataxia, infertility, increased sensitivity to ionising radiation, and an …

The advent of next-generation sequencing technologies has empowered genetic research
of human immunoglobulin variable region and T-cell receptor gene repertoires to move …