Metabolism and biomarkers of heterocyclic aromatic amines in humans

M Bellamri, SJ Walmsley, RJ Turesky - Genes and Environment, 2021 - Springer
Heterocyclic aromatic amines (HAAs) form during the high-temperature cooking of meats,
poultry, and fish. Some HAAs also arise during the combustion of tobacco. HAAs are …

Extension of diagnostic fragmentation filtering for automated discovery in DNA adductomics

KJ Murray, ES Carlson, A Stornetta… - Analytical …, 2021 - ACS Publications
Development of high-resolution/accurate mass liquid chromatography-coupled tandem
mass spectrometry (LC–MS/MS) methodology enables the characterization of covalently …

A novel potent inhibitor of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) formation from Chinese chive: Identification, inhibitory effect and action …

Q Wang, W Cheng, Y Zhang, Q Kang, V Gowd, Y Ren… - Food Chemistry, 2021 - Elsevier
Differential solvent extraction and phytochemical profiling of Chinse chive were employed to
identify its principal PhIP-formation inhibitory constituents. Six compounds (mangiferin …

Comprehensive Analysis of DNA Adducts Using Data-Independent wSIM/MS2 Acquisition and wSIM-City

SJ Walmsley, J Guo, P Murugan, CJ Weight… - Analytical …, 2021 - ACS Publications
A novel software has been created to comprehensively characterize covalent modifications
of DNA through mass spectral analysis of enzymatically hydrolyzed DNA using the neutral …

Mutagenicity of 2-hydroxyamino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (N–OH-PhIP) in human TP53 knock-in (Hupki) mouse embryo fibroblasts

L Hölzl-Armstrong, S Moody, JE Kucab… - Food and Chemical …, 2021 - Elsevier
Amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) is a possible human carcinogen
formed in cooked fish and meat. PhIP is bioactivated by cytochrome P450 enzymes to form 2 …

Screening of extraction methods for use in the detection of 16 heterocyclic amines in meat products by ultra-high performance liquid chromatography-tandem mass …

X Ding, T Hui, X Bai, Z Wang, D Zhang - 2021 - cabidigitallibrary.org
In this work, two tandem solid phase extraction (SPE) methods (Extrelut-PRS-C18 and PRS-
C18 SPE columns), MCX SPE column extraction and dispersive SPE (quick, easy, cheap …