Targeting inflammation in atherosclerosis—from experimental insights to the clinic
O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …
inflammation from its inception to the emergence of complications. Targeting inflammatory …
PPAR control of metabolism and cardiovascular functions
D Montaigne, L Butruille, B Staels - Nature Reviews Cardiology, 2021 - nature.com
Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …
factors that regulate gene expression following ligand activation. PPARα increases cellular …
Intermittent and periodic fasting, longevity and disease
Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to
affect longevity and healthspan by acting on cellular aging and disease risk factors, while …
affect longevity and healthspan by acting on cellular aging and disease risk factors, while …
[HTML][HTML] The effects of intermittent fasting on brain and cognitive function
The importance of diet and the gut-brain axis for brain health and cognitive function is
increasingly acknowledged. Dietary interventions are tested for their potential to prevent …
increasingly acknowledged. Dietary interventions are tested for their potential to prevent …
Mechanisms mediating the regulation of peroxisomal fatty acid beta-oxidation by PPARα
M Tahri-Joutey, P Andreoletti, S Surapureddi… - International journal of …, 2021 - mdpi.com
In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …
performing flow cytometry experiments and includes comprehensive sections describing …
Emerging concepts in intestinal immune control of obesity-related metabolic disease
The intestinal immune system is an important modulator of glucose homeostasis and obesity-
associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites …
associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites …
IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2
Aging impairs the integrated immunometabolic responses, which have evolved to maintain
core body temperature in homeotherms to survive cold stress, infections, and dietary …
core body temperature in homeotherms to survive cold stress, infections, and dietary …
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases
Recent and accumulating work in experimental animal models and humans shows that diet
has a much more pervasive and prominent role than previously thought in modulating …
has a much more pervasive and prominent role than previously thought in modulating …
A high-fat diet attenuates AMPK α1 in adipocytes to induce exosome shedding and nonalcoholic fatty liver development in vivo
C Yan, X Tian, J Li, D Liu, D Ye, Z Xie, Y Han… - Diabetes, 2021 - Am Diabetes Assoc
Exosomes are important for intercellular communication, but the role of exosomes in the
communication between adipose tissue (AT) and the liver remains unknown. The aim of this …
communication between adipose tissue (AT) and the liver remains unknown. The aim of this …