Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance
Recent developments of organoids engineering and organ-on-a-chip microfluidic
technologies have enabled the recapitulation of the major functions and architectures of …
technologies have enabled the recapitulation of the major functions and architectures of …
Sex differences in the blood–brain barrier and neurodegenerative diseases
The number of people diagnosed with neurodegenerative diseases is on the rise. Many of
these diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and …
these diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and …
Artificial intelligence velocimetry and microaneurysm-on-a-chip for three-dimensional analysis of blood flow in physiology and disease
Understanding the mechanics of blood flow is necessary for developing insights into
mechanisms of physiology and vascular diseases in microcirculation. Given the limitations of …
mechanisms of physiology and vascular diseases in microcirculation. Given the limitations of …
Role of purinergic signalling in endothelial dysfunction and thrombo-inflammation in ischaemic stroke and cerebral small vessel disease
The cerebral endothelium is an active interface between blood and the central nervous
system. In addition to being a physical barrier between the blood and the brain, the …
system. In addition to being a physical barrier between the blood and the brain, the …
Quantitative prediction of flow dynamics and mechanical retention of surface-altered red blood cells through a splenic slit
Normal red blood cells (RBCs) have remarkable properties of deformability, which enable
them to squeeze through tiny splenic inter-endothelial slits (IESs) without any damage …
them to squeeze through tiny splenic inter-endothelial slits (IESs) without any damage …
A mesoscale computational model for microvascular oxygen transfer
L Possenti, A Cicchetti, R Rosati, D Cerroni… - Annals of Biomedical …, 2021 - Springer
We address a mathematical model for oxygen transfer in the microcirculation. The model
includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen …
includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen …
[HTML][HTML] Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation
A Bornert, J Boscher, F Pertuy, A Eckly, D Stegner… - …, 2021 - ncbi.nlm.nih.gov
Platelets are produced by bone marrow megakaryocytes through cytoplasmic protrusions,
named native proplatelets (nPPT), into blood vessels. Proplatelets also refer to protrusions …
named native proplatelets (nPPT), into blood vessels. Proplatelets also refer to protrusions …
Reciprocal theorem for calculating the flow rate–pressure drop relation for complex fluids in narrow geometries
E Boyko, HA Stone - Physical Review Fluids, 2021 - APS
We study the mechanically driven flows of non-Newtonian fluids in narrow and confined
configurations. Using the Lorentz reciprocal theorem, we derive a closed-form expression for …
configurations. Using the Lorentz reciprocal theorem, we derive a closed-form expression for …
Margination and adhesion dynamics of tumor cells in a real microvascular network
In tumor metastasis, the margination and adhesion of tumor cells are two critical and closely
related steps, which may determine the destination where the tumor cells extravasate to. We …
related steps, which may determine the destination where the tumor cells extravasate to. We …
Emergent cell-free layer asymmetry and biased haematocrit partition in a biomimetic vascular network of successive bifurcations
Blood is a vital soft matter, and its normal circulation in the human body relies on the
distribution of red blood cells (RBCs) at successive bifurcations. Understanding how RBCs …
distribution of red blood cells (RBCs) at successive bifurcations. Understanding how RBCs …