[HTML][HTML] Anions-responsive supramolecular gels: A review

L Li, R Sun, R Zheng, Y Huang - Materials & Design, 2021 - Elsevier
Recently, supramolecular low-molecular-weight gels have attracted more and more
attentions and have potential applications in many areas due to the dynamic nature of …

Dysregulation of astrocyte ion homeostasis and its relevance for stroke-induced brain damage

MJAM van Putten, C Fahlke, KW Kafitz… - International journal of …, 2021 - mdpi.com
Ischemic stroke is a leading cause of mortality and chronic disability. Either recovery or
progression towards irreversible failure of neurons and astrocytes occurs within minutes to …

[HTML][HTML] Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior

B Dudok, M Szoboszlay, A Paul, PM Klein, Z Liao… - Neuron, 2021 - cell.com
The axon initial segment of hippocampal pyramidal cells is a key subcellular compartment
for action potential generation, under GABAergic control by the" chandelier" or axo-axonic …

A pilot randomized, controlled, double‐blind trial of bumetanide to treat neonatal seizures

JS Soul, AM Bergin, C Stopp, B Hayes… - Annals of …, 2021 - Wiley Online Library
Objective In the absence of controlled trials, treatment of neonatal seizures has changed
minimally despite poor drug efficacy. We tested bumetanide added to phenobarbital to treat …

A ratiometric photoelectrochemical microsensor based on a small-molecule organic semiconductor for reliable in vivo analysis

Y Xiang, Y Kong, W Feng, X Ye, Z Liu - Chemical Science, 2021 - pubs.rsc.org
Photoelectrochemical (PEC) sensing has been developing quickly in recent years, while its
in vivo application is still in the infancy. The complexity of biological environments poses a …

Unique actions of GABA arising from cytoplasmic chloride microdomains

N Rahmati, KP Normoyle, J Glykys… - Journal of …, 2021 - Soc Neuroscience
Developmental, cellular, and subcellular variations in the direction of neuronal Cl–currents
elicited by GABA A receptor activation have been frequently reported. We found a …

Targeting the WNK-SPAK/OSR1 pathway and cation-chloride cotransporters for the therapy of stroke

SS Josiah, NF Meor Azlan, J Zhang - International Journal of Molecular …, 2021 - mdpi.com
Stroke is one of the major culprits responsible for morbidity and mortality worldwide, and the
currently available pharmacological strategies to combat this global disease are scanty …

KCC2 chloride transport contributes to the termination of ictal epileptiform activity

VI Dzhala, KJ Staley - Eneuro, 2021 - eneuro.org
Recurrent seizures intensely activate GABAA receptors (GABAA-Rs), which induces
transient neuronal chloride ([Cl–] i) elevations and depolarizing GABA responses that …

Meta-analytic evidence for volume increases in the medial temporal lobe after electroconvulsive therapy

H Janouschek, JA Camilleri… - Biological …, 2021 - biologicalpsychiatryjournal.com
Since its introduction to psychiatric practice more than 8 decades ago, electroconvulsive
therapy (ECT) is widely recognized as a highly effective treatment for severe psychiatric …

[HTML][HTML] A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial …

B Costine-Bartell, G Price, J Shen, D McGuone… - Neurobiology of …, 2021 - Elsevier
The pathophysiology of extensive cortical tissue destruction observed in hemispheric
hypodensity, a severe type of brain injury observed in young children, is unknown. Here, we …