Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …

A series of fluorescent ligands, which were systematically constructed from thiazole orange
scaffold, was investigated for their interactions with G-quadruplex structures and antitumor …

Extensive evidence indicates that RNA G-quadruplexes have associated with some
important cellular events. Investigation of RNA G-quadruplexes is thus vital to revealing their …

G-quadruplexes (G4s) continue to gather wide attention in the field of chemical biology as
their prevalence in the human genome and transcriptome strongly suggests that they play …

Oxazole-type fluorophores show an increase of fluorescence intensity upon interaction with
nucleic acids, and therefore can be used as tools for nucleic acid-sensing and fluorescence …

Herein, we designed and synthesized a compound, Di-TPE, which has the torsional, locked
stacking effect in aggregation with aggregation-induced emission properties in solution. The …

G-quadruplexes (G4) are the most actively studied non-canonical secondary structures
formed by contiguous repeats of guanines in DNA or RNA strands. Small molecule mediated …