RNA G-quadruplexes (rG4s): genomics and biological functions
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …
have been first observed decades ago. Over the years, these four-stranded structural motifs …
[HTML][HTML] G-quadruplexes and their ligands: Biophysical methods to unravel G-quadruplex/ligand interactions
Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of
approaches that assess the binding mode and nature of the interactions between G4 …
approaches that assess the binding mode and nature of the interactions between G4 …
Molecular recognition and imaging of human telomeric G-quadruplex DNA in live cells: a systematic advancement of thiazole orange scaffold to enhance binding …
W Long, BX Zheng, XH Huang, MT She… - Journal of medicinal …, 2021 - ACS Publications
A series of fluorescent ligands, which were systematically constructed from thiazole orange
scaffold, was investigated for their interactions with G-quadruplex structures and antitumor …
scaffold, was investigated for their interactions with G-quadruplex structures and antitumor …
Recent advances in the development of small molecules targeting RNA G-quadruplexes for drug discovery
Y Tao, Y Zheng, Q Zhai, D Wei - Bioorganic Chemistry, 2021 - Elsevier
Extensive evidence indicates that RNA G-quadruplexes have associated with some
important cellular events. Investigation of RNA G-quadruplexes is thus vital to revealing their …
important cellular events. Investigation of RNA G-quadruplexes is thus vital to revealing their …
Biomimetic, smart, and multivalent ligands for G-quadruplex isolation and bioorthogonal imaging
FR Sperti, T Charbonnier, P Lejault, J Zell… - ACS Chemical …, 2021 - ACS Publications
G-quadruplexes (G4s) continue to gather wide attention in the field of chemical biology as
their prevalence in the human genome and transcriptome strongly suggests that they play …
their prevalence in the human genome and transcriptome strongly suggests that they play …
Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand
Y Ma, Y Wakabayashi, N Watatani, R Saito… - Organic & …, 2021 - pubs.rsc.org
Oxazole-type fluorophores show an increase of fluorescence intensity upon interaction with
nucleic acids, and therefore can be used as tools for nucleic acid-sensing and fluorescence …
nucleic acids, and therefore can be used as tools for nucleic acid-sensing and fluorescence …
The aggregation-induced emission of Methyl-bis-(4-triphenylvinyl-benzyl)-amine in solution with torsional and locked stacking effects
M Qin, Z Wu, J Zhang, X Xing, L Zhu, Y Zhong… - Journal of Molecular …, 2021 - Elsevier
Herein, we designed and synthesized a compound, Di-TPE, which has the torsional, locked
stacking effect in aggregation with aggregation-induced emission properties in solution. The …
stacking effect in aggregation with aggregation-induced emission properties in solution. The …
[HTML][HTML] Assessing G4-binding ligands in vitro and in cellulo using dimeric carbocyanine dye displacement assay
G-quadruplexes (G4) are the most actively studied non-canonical secondary structures
formed by contiguous repeats of guanines in DNA or RNA strands. Small molecule mediated …
formed by contiguous repeats of guanines in DNA or RNA strands. Small molecule mediated …