Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …

CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Despite enormous progress in the treatment of many malignancies, the development of
cancer resistance is still an important reason for cancer chemotherapy failure. Increasing …

CK2 is a protein kinase involved in several human diseases (ranging from neurological and
cardiovascular diseases to autoimmune disorders, diabetes, and infections, including …

CK2 is a constitutively active protein kinase that assuring a constant level of phosphorylation
to its numerous substrates supports many of the most important biological functions …

Disturbance of protein kinase activity may result in dramatic consequences that often lead to
cancer development and progression. In tumors of blood origin, both tyrosine kinases and …

Protein kinase CK2, formally known as casein kinase II, is ubiquitously expressed and highly
conserved serine/threonine or tyrosine kinase enzyme that regulates diverse signaling …

Protein Kinase CK2, a constitutively active serine/threonine kinase, fulfills its functions via
phosphorylating hundreds of proteins in nearly all cells. It regulates a variety of cellular …

Protein kinase CK2 has been considered as an attractive drug target for anti-cancer therapy.
The synthesis of N-hydroxypropyl TBBi and 2MeTBBi derivatives as well as their respective …

Multiple myeloma (MM) is a cancer that begins in the plasma cells (PC) and progresses to
the bone marrow. It is a recurring disease, as no definitive solution can be found despite the …