The formation of peptide bonds is one of the most important biochemical reaction steps.
Without the development of structurally and catalytically active polymers, there would be no …

Many fundamental cellular and viral functions, including replication and translation, involve
complex ensembles hosting synergistic activity between nucleic acids and …

Discovering autocatalytic chemistries that can evolve is a major goal in systems chemistry
and a critical step towards understanding the origin of life. Autocatalytic networks have been …

Formation of dehydroalanine and dehydrobutyrine residues via tRNA-dependent
dehydration of serine and threonine is a key post-translational modification in the …

Self-assembly of short peptides has emerged as an interesting research field for a wide
range of applications. Recently, several truncated fragments of long-chain peptides or …

The self‐assembly of short peptides into catalytic amyloid‐like nanomaterials has proven to
be a powerful tool in both understanding the evolution of early proteins and identifying new …

The condensation of building blocks into oligomers and polymers was an early and
important stage in the origins of life. High activation energies, unfavorable thermodynamics …

The formation of peptide bonds is one of the most important biochemical reaction steps.
Without the 22 development of structurally and catalytically active polymers, there would be …

Although scientists do not agree on one definition of life,[1] it is commonly held that it
displays certain features, such as metabolism, growth, reproduction and evolution. What …