[HTML][HTML] The microbiota in cirrhosis and its role in hepatic decompensation

J Trebicka, J Macnaughtan, B Schnabl… - Journal of …, 2021 - Elsevier
Cirrhosis–the common end-stage of chronic liver disease–is associated with a cascade of
events, of which intestinal bacterial overgrowth and dysbiosis are central. Bacterial toxins …

[HTML][HTML] The gut-liver axis in health and disease: The role of gut microbiota-derived signals in liver injury and regeneration

Z Zheng, B Wang - Frontiers in immunology, 2021 - frontiersin.org
Diverse liver diseases undergo a similar pathophysiological process in which liver
regeneration follows a liver injury. Given the important role of the gut-liver axis in health and …

[HTML][HTML] Gut microbiota and NAFLD: pathogenetic mechanisms, microbiota signatures, and therapeutic interventions

T Hrncir, L Hrncirova, M Kverka, R Hromadka… - Microorganisms, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Its
worldwide prevalence is rapidly increasing and is currently estimated at 24%. NAFLD is …

Gut–organ axis: a microbial outreach and networking

S Ahlawat, Asha, KK Sharma - Letters in applied microbiology, 2021 - academic.oup.com
Human gut microbiota (GM) includes a complex and dynamic population of microorganisms
that are crucial for well‐being and survival of the organism. It has been reported as diverse …

[HTML][HTML] Alterations in gut microbiome in cirrhosis as assessed by quantitative metagenomics: relationship with acute-on-chronic liver failure and prognosis

C Solé, S Guilly, K Da Silva, M Llopis, E Le-Chatelier… - Gastroenterology, 2021 - Elsevier
Background and Aims Cirrhosis is associated with changes in gut microbiome composition.
Although acute-on-chronic liver failure (ACLF) is the most severe clinical stage of cirrhosis …

[HTML][HTML] Environmental influences on the human microbiome and implications for noncommunicable disease

J Ahn, RB Hayes - Annual review of public health, 2021 - annualreviews.org
The human microbiome contributes metabolic functions, protects against pathogens,
educates the immune system, and through these basic functions, directly or indirectly, affects …

Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury

L Wrzosek, D Ciocan, C Hugot, M Spatz, M Dupeux… - Gut, 2021 - gut.bmj.com
Objective Chronic alcohol consumption is an important cause of liver-related deaths.
Specific intestinal microbiota profiles are associated with susceptibility or resistance to …

Targeting the gut-liver-immune axis to treat cirrhosis

TH Tranah, LA Edwards, B Schnabl, DL Shawcross - Gut, 2021 - gut.bmj.com
Cirrhotic portal hypertension is characterised by development of the decompensating events
of ascites, encephalopathy, portal hypertensive bleeding and hepatorenal syndrome, which …

[HTML][HTML] Leaky gut and gut-liver axis in liver cirrhosis: clinical studies update

H Fukui - Gut and liver, 2021 - ncbi.nlm.nih.gov
Portal blood flows into the liver containing the gut microbiome and its products such as
endotoxin and bacterial DNA. The cirrhotic liver acts and detoxifies as the initial site of …

[HTML][HTML] Role of microbiota-derived metabolites in alcoholic and non-alcoholic fatty liver diseases

JW Park, SE Kim, NY Lee, JH Kim, JH Jung… - International Journal of …, 2021 - mdpi.com
Chronic liver disease encompasses diseases that have various causes, such as alcoholic
liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Gut microbiota …