Driver mutations promote initiation and progression of cancer. Pharmacological treatment
can inhibit the action of the mutant protein; however, drug resistance almost invariably …

Chemotherapy remains a powerful tool to eliminate malignant cells. However, the efficacy of
chemotherapy is compromised by the frequent emergence of intrinsic and acquired …

Over the past decades, significant progress has been made in targeted cancer therapy. In
precision oncology, molecular profiling of cancer patients enables the use of targeted cancer …

Alternative splicing (AS) of RNA is a key mechanism that results in the expression of multiple
transcript isoforms from single genes and leads to an increase in the complexity of both the …

Arsenic is a ubiquitous metalloid whose high levels of toxicity pose major health concerns to
millions of people worldwide by increasing susceptibility to various cancers and non-cancer …

Cancer is a multifaceted disease that involves several molecular mechanisms including
changes in gene expression. Two important processes altered in cancer that lead to …

Cancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and
differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect …

More than 95% of all human genes are alternatively spliced after transcription, which
enriches the diversity of proteins and regulates transcript and/or protein levels. The splicing …

Aberrant N6-methyladenosine (m6A) RNA methylation regulatory genes and related gene
alternative splicing (AS) could be used to predict the prognosis of non–small cell lung …

Almost all transcribed human genes undergo alternative RNA splicing, which increases the
diversity of the coding and non-coding cellular landscape. The resultant gene products …