Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western
countries and is an example of hematological disease where cooperation between genetic …

Bone skeletal alterations are no longer considered a rare event in chronic lymphocytic
leukemia (CLL), especially at more advanced stages of the disease. This study is aimed at …

Survival of chronic lymphocytic leukemia (CLL) cells critically depends on the support of an
adapted and therefore appropriate tumor microenvironment. Increasing evidence suggests …

ABSTRACT OBJECTIVE: Cytokines produced by bone marrow mesenchymal stem cells are
important components of the tumor microenvironment in chronic lymphocytic leukemia …

Despite the advent of even more effective therapies, Chronic Lymphocytic Leukemia (CLL)
is still incurable and patients often develop drug resistance. We and others have found that …

Molecular targets of tyrosine kinase inhibitors are not restricted to the B-cell compartment but
also regulate functions in the tumor microenvironment. Increasing evidence suggests that B …

The recent success of targeted anticancer therapeutics has propelled cancer genomics to
the forefront of clinical oncology. Patients with actionable mutations can now be treated with …

Sunlight represents a dominating environmental factor for most organisms on earth. Animals
and plants have evolved different strategies to perceive sunlight and to effectively mobilize it …

Mantle cell lymphoma (MCL) and chronic lymphocytic leukaemia (CLL) are two incurable B
cell malignancies, with an overall survival of 5 to 8 years and 6 to 10 years, respectively …