The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

Abstract Background Both Chili pepper (CP) and Sichuan pepper (SP) have long been used
for culinary purposes throughout Asia. It is well known CP and SP are well accompanied in …

The year 2020 became the year of the outbreak of coronavirus, SARS-CoV-2, which
escalated into a worldwide pandemic and continued into 2021. One of the unique symptoms …

Crystal structures activate innate immune cells, especially macrophages and initiate
inflammatory responses. We aimed to understand the role of the mechanosensitive TRPV4 …

In addition to the sense of taste and olfaction, chemesthesis, the sensation of irritation,
pungency, cooling, warmth, or burning elicited by spices and herbs, plays a central role in …

Every day our sensory systems perceive and integrate a variety of stimuli containing
information vital for our survival. Pain acts as a protective warning system, eliciting a …

The essential oil (EO) of the herbal pair (HP), Alpinia officinarum‐Cyperus rotundus (HP G‐
X) has been conventionally used in traditional Chinese medicine (TCM) for 'warming the …

The quantitation of pungency is difficult to achieve using sensory tests because of
persistence, accumulation, and desensitization to the perception of pungency. Transient …

Cancer is an aging-associated disease and caused by genomic instability that is driven by
the accumulation of mutations and epimutations in the aging process. Although Ca 2+ …

Canonical Transient Receptor Potential channels (TRPC-Kanäle) bilden nicht-selektive
Ca2+-permeable Kanäle. Sie sind im Gehirn weit verbreitet, aber ihre Funktion ist bisher …