Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …

The rapid and efficient phagocytic clearance of apoptotic cells, termed efferocytosis, is a
critical mechanism in the maintenance of tissue homeostasis. Removal of apoptotic cells …

Cross-presentation of antigens from dead tumor cells by type 1 conventional dendritic cells
(cDC1s) is thought to underlie priming of anti-cancer CD8+ T cells. cDC1 express high …

Macropinocytosis is a form of endocytosis performed by ruffles and cups of the plasma
membrane. These close to entrap droplets of medium into micron-sized vesicles, which are …

Dendritic cells (DCs) are key immune sentinels that orchestrate protective immune
responses against pathogens or cancers. DCs have evolved into multiple phenotypically …

Reactive oxygen species (ROS) derived from the phagocyte NADPH oxidase (NOX2) are
essential for host defence and immunoregulation. Their levels must be tightly controlled …

Trogocytosis is an active process whereby plasma membrane proteins are transferred from
one cell to the other cell in a cell-cell contact-dependent manner. Since the discovery of the …

Simple Summary Cancer is one of the leading causes of mortality around the globe. In the
past decades, there has been rapid progress in the development of tools to detect, screen …

The humoral immune response to SARS‐CoV‐2 results in antibodies against spike (S) and
nucleoprotein (N). However, whilst there are widely available neutralization assays for S …

The membranes of endosomes, phagosomes and macropinosomes can become damaged
by the physical properties of internalized cargo, by active pathogenic invasion or by cellular …