Retinal imaging in Alzheimer's and neurodegenerative diseases

PJ Snyder, J Alber, C Alt, LJ Bain… - Alzheimer's & …, 2021 - Wiley Online Library
In the last 20 years, research focused on developing retinal imaging as a source of potential
biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased …

Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances

VB Gupta, N Chitranshi, J den Haan, M Mirzaei… - Progress in retinal and …, 2021 - Elsevier
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …

Past, present and future role of retinal imaging in neurodegenerative disease

AH Kashani, S Asanad, JW Chan, MB Singer… - Progress in retinal and …, 2021 - Elsevier
Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts
of information about the structure, function and molecular composition of retinal tissue in …

Retinal biomarkers in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis

YJ Ge, W Xu, YN Ou, Y Qu, YH Ma, YY Huang… - Ageing Research …, 2021 - Elsevier
Background Retinal changes may reflect the pathophysiological processes in the central
nervous system and can be assessed by imaging modalities non-invasively. We aim to …

Retinal vasculopathy in Alzheimer's disease

H Shi, Y Koronyo, A Rentsendorj, DT Fuchs… - Frontiers in …, 2021 - frontiersin.org
The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …

Role of retinal amyloid-β in neurodegenerative diseases: overlapping mechanisms and emerging clinical applications

L Wang, X Mao - International journal of molecular sciences, 2021 - mdpi.com
Amyloid-β (Aβ) accumulations have been identified in the retina for neurodegeneration-
associated disorders like Alzheimer's disease (AD), glaucoma, and age-related macular …

Optical coherence tomography in patients with Alzheimer's disease: what can it tell us?

A Song, N Johnson, A Ayala, AC Thompson - Eye and brain, 2021 - Taylor & Francis
Purpose Although Alzheimer's disease (AD) is a leading cause of dementia worldwide, its
clinical diagnosis remains a challenge. Optical coherence tomography (OCT) and OCT with …

Hyperspectral mapping for the detection of SARS-CoV-2 using nanomolecular probes with yoctomole sensitivity

M Alafeef, P Moitra, K Dighe, D Pan - ACS nano, 2021 - ACS Publications
Efficient monitoring of SARS-CoV-2 outbreak requires the use of a sensitive and rapid
diagnostic test. Although SARS-CoV-2 RNA can be detected by RT-qPCR, the molecular …

Ophthalmic biomarkers for Alzheimer's disease: a review

A Majeed, B Marwick, H Yu, H Fadavi… - Frontiers in Aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
neuronal loss, extracellular amyloid-β (Aβ) plaques, and intracellular neurofibrillary tau …

The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research

M Vandenabeele, L Veys, S Lemmens… - Acta neuropathologica …, 2021 - Springer
In this study, we report the results of a comprehensive phenotyping of the retina of the App
NL-GF mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these …