Potential therapeutic targets and vaccine development for SARS-CoV-2/COVID-19 pandemic management: a review on the recent update

U Anand, S Jakhmola, O Indari, HC Jha… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly pathogenic
novel virus that has caused a massive pandemic called coronavirus disease 2019 (COVID …

Heparan sulfate proteoglycans in viral infection and treatment: a special focus on SARS-CoV-2

V De Pasquale, MS Quiccione, S Tafuri… - International Journal of …, 2021 - mdpi.com
Heparan sulfate proteoglycans (HSPGs) encompass a group of glycoproteins composed of
unbranched negatively charged heparan sulfate (HS) chains covalently attached to a core …

The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor

Y Hu, X Meng, F Zhang, Y Xiang… - Emerging microbes & …, 2021 - Taylor & Francis
ABSTRACT Coronavirus disease 2019 (COVID-19) is an ongoing pandemic that lacks
effective therapeutic interventions. SARS-CoV-2 infects ACE2-expressing cells and gains …

SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration

D Idrees, V Kumar - Biochemical and biophysical research communications, 2021 - Elsevier
The post-infection of COVID-19 includes a myriad of neurologic symptoms including
neurodegeneration. Protein aggregation in brain can be considered as one of the important …

The unifying hypothesis of Alzheimer's disease: Heparan sulfate proteoglycans/glycosaminoglycans are key as first hypothesized over 30 years ago

AD Snow, JA Cummings, T Lake - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
The updated “Unifying Hypothesis of Alzheimer's disease”(AD) is described that links all the
observed neuropathology in AD brain (ie, plaques, tangles, and cerebrovascular amyloid …

[HTML][HTML] Endothelial cells and SARS-CoV-2: An intimate relationship

LC Barbosa, TL Goncalves, LP de Araujo… - Vascular …, 2021 - Elsevier
Abstract Angiotensin-converting enzyme 2 (ACE2) is an important player of the renin-
angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II into …

Antiviral peptides against Coronaviridae family: A review

H Heydari, R Golmohammadi, R Mirnejad… - Peptides, 2021 - Elsevier
The Coronaviridae family comprises large enveloped single-stranded RNA viruses. The
known human-infecting coronaviruses; severe acute respiratory syndrome coronavirus …

Cardiovascular protective properties of oxytocin against COVID-19

SC Wang, YF Wang - Life Sciences, 2021 - Elsevier
SARS-CoV-2 infection or COVID-19 has become a worldwide pandemic; however, effective
treatment for COVID-19 remains to be established. Along with acute respiratory distress …

A Case Report of a Patient on Therapeutic Warfarin Who Died of COVID-19 Infection with a Sudden Rise in D-Dimer

RN Agarwal, H Aggarwal, A Verma, MK Tripathi - Biomedicines, 2021 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has disrupted
social and economic life globally. The global pandemic COVID-19 caused by this novel …

METHYLENE BLUE INHIBITS THE INTERACTION BETWEEN HEPARAN SULFATE AND SARS-COV-2 SPIKE PROTEIN; A REVIEW OF EVIDENCE FOR A …

NLR Indika, NG Fonseka - Malaysian Journal of Medical Research …, 2021 - ejournal.lucp.net
The addition of methylene blue to the standard treatment protocol has been shown to
improve respiratory rate and oxygen saturation in COVID-19 patients, reducing morbidity …