The falsification of data related to c-kit+ cardiac progenitor cells (CPCs) by a Harvard
laboratory has been a veritable tragedy. Does this fraud mean that CPCs are not beneficial …

Cardiovascular diseases represent the world's leading cause of death. In this
heterogeneous group of diseases, ischemic cardiomyopathies are the most devastating and …

Serious side effects from chemotherapies are the main problem with cancer treatments. To
solve these issues, precision cancer nanomedicine based on natural therapeutic materials …

Rationale Cell-based therapeutics have been extensively used for cardiac repair yet
underperform due to inability of the donated cells to survive in near anoxia after cardiac …

Cellular replacement in the heart is restricted to postnatal stages with the adult heart largely
postmitotic. Studies show that loss of regenerative properties in cardiac cells seems to …

Metabolism has emerged as a regulator of core stem cell properties such as proliferation,
survival, self-renewal, and multilineage potential. Metabolites serve as secondary …

Embodiments of the disclosure concern compositions and methods of use related to
particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric …