Drug treatments available for the management of substance use disorders (SUD) present
multiple limitations in efficacy, lack of approved treatments or alarming relapse rates. These …

Cannabis sativa is the most widely used illicit drug in the world. Its main psychoactive
component is delta‐9‐tetrahydrocannabinol (THC), one of over 100 phytocannabinoid …

The endocannabinoid system (ECS) is involved in a variety of brain functions, mainly
through the activation of the type-1 cannabinoid receptors (CB1R). CB1R are highly …

Although research has only recently started to examine the impact of cannabis use on stress
response, there is some evidence that indicates acute and chronic impacts of cannabis on …

Background and aims Research from cohorts of individuals with recreational cannabis use
indicates that cannabis withdrawal symptoms are reported by more than 40% of those using …

Objective: Research has documented the relationship between attention-deficit/hyperactivity
disorder (ADHD) and increased cannabis use, but the studies largely rely on cross-sectional …

The aim was to summarize post-acute withdrawal syndrome (PAWS) for the most common
psychoactive substances, including alcohol, benzodiazepines, opioids, stimulants, and …

Sleep disturbance is a common symptom encountered by cannabis‐dependent individuals
abstaining from cannabis use. In the present study, we investigated the effect of daily …

Withdrawal symptoms are observed upon cessation of cannabis use in humans. Although
animal studies have examined withdrawal symptoms following exposure to delta-9 …

The first foundational text on the clinical use of cannabis and cannabinoid therapies. Despite
thousands of years of medical use and an impressive record of safety, versatility, and …