[HTML][HTML] Defining the underlying defect in insulin action in type 2 diabetes
Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over
the past 50 years, elucidation of the insulin signalling network has provided important …
the past 50 years, elucidation of the insulin signalling network has provided important …
[HTML][HTML] Redox regulation of PTEN by peroxiredoxins
T Nguyen Huu, J Park, Y Zhang, I Park, HJ Yoon… - Antioxidants, 2021 - mdpi.com
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known as a tumor
suppressor gene that is frequently mutated in numerous human cancers and inherited …
suppressor gene that is frequently mutated in numerous human cancers and inherited …
[PDF][PDF] Skeletal muscle proteomes reveal downregulation of mitochondrial proteins in transition from prediabetes into type 2 diabetes
Skeletal muscle insulin resistance is a central defect in the pathogenesis of type 2 diabetes
(T2D). Here, we analyzed skeletal muscle proteome in 148 vastus lateralis muscle biopsies …
(T2D). Here, we analyzed skeletal muscle proteome in 148 vastus lateralis muscle biopsies …
[HTML][HTML] Sestrin2 as a potential target for regulating metabolic-related diseases
L Gong, Z Wang, Z Wang, Z Zhang - Frontiers in Endocrinology, 2021 - frontiersin.org
Sestrin2 is a highly conserved protein that can be induced under a variety of stress
conditions, including DNA damage, oxidative stress, endoplasmic reticulum (ER) stress, and …
conditions, including DNA damage, oxidative stress, endoplasmic reticulum (ER) stress, and …
[PDF][PDF] Signaling heterogeneity is defined by pathway architecture and intercellular variability in protein expression
Insulin's activation of PI3K/Akt signaling, stimulates glucose uptake by enhancing delivery of
GLUT4 to the cell surface. Here we examined the origins of intercellular heterogeneity in …
GLUT4 to the cell surface. Here we examined the origins of intercellular heterogeneity in …
[HTML][HTML] In Vitro 31P MR Chemical Shifts of In Vivo-Detectable Metabolites at 3T as a Basis Set for a Pilot Evaluation of Skeletal Muscle and Liver 31P Spectra with …
P Sedivy, T Dusilova, M Hajek, M Burian, M Krššák… - Molecules, 2021 - mdpi.com
Most in vivo 31P MR studies are realized on 3T MR systems that provide sufficient signal
intensity for prominent phosphorus metabolites. The identification of these metabolites in the …
intensity for prominent phosphorus metabolites. The identification of these metabolites in the …
[HTML][HTML] Comparing the effect of cinnamaldehyde and metformin on expression of MiR320 and MiR26-b in insulin resistant 3T3L1 adipocytes
Abstract Background Some micro-RNAs are linked with insulin resistance and their related
signals. They can act as a predicting factor for respond to anti-diabetic medications …
signals. They can act as a predicting factor for respond to anti-diabetic medications …
Human serum metabolomic analysis reveals progression for high blood pressure in type 2 diabetes mellitus
Y Zhang, H Zhao, B Liu, H Shu, L Zhang… - BMJ Open Diabetes …, 2021 - drc.bmj.com
Introduction Type 2 diabetes mellitus (T2DM) is one of the most ordinary metabolic disorders
and manifests as a high blood sugar level; 80%–90% of patients with T2DM will develop …
and manifests as a high blood sugar level; 80%–90% of patients with T2DM will develop …
Baru Nut Intake and Resistance Training Practice have Potential to Reduce the Cardiometabolic Risk Factors in Type 2 Diabetes
Background: Type 2 diabetes mellitus (T2DM) is a disease associated with several
cardiometabolic risk factors (CMRF). There is strong evidence about the benefits of oilseeds …
cardiometabolic risk factors (CMRF). There is strong evidence about the benefits of oilseeds …
Focused Ultrasound Modulation of Hepatic Neural Plexus Restores Glucose Homeostasis in Diabetes
V Cotero, H Miwa, Z Hirschstein, K Qanud, TS Huerta… - bioRxiv, 2021 - biorxiv.org
While peripheral glucose sensors are known to relay signals of substrate availability to
integrative nuclei in the brain, the importance of these pathways in maintaining energy …
integrative nuclei in the brain, the importance of these pathways in maintaining energy …