Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …

Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of a clonally
expanded hematopoietic stem cell caused by a leukemogenic mutation in individuals …

Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and
senescence. Here we characterize the genetic architecture of naturally occurring variation in …

Telomeres are regions of repetitive nucleotide sequences at the ends of chromosomes.
Telomere length is a marker of DNA damage, which is often considered a biomarker for …

Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease accounting for 1% of
UK deaths. In the familial form of pulmonary fibrosis, causal genes have been identified in …

Simple Summary A link between telomere length and some age-related diseases has been
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …

Telomeres are at the non-coding ends of linear chromosomes. Through a complex 3-
dimensional structure, they protect the coding DNA and ensure appropriate separation of …

Chronic kidney disease (CKD) is highly prevalent in the elderly population. However, it is
rarely investigated whether kidney function is causally linked to biological aging itself. In this …

Higher levels of omega-3 track with longer telomeres, lower inflammation, and blunted
sympathetic and cardiovascular stress reactivity. Whether omega-3 supplementation alters …

Background We previously investigated the association between 5 “first-generation”
measures of epigenetic aging and cancer risk in the Melbourne Collaborative Cohort Study …