Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors

AP Klein - Nature reviews Gastroenterology & hepatology, 2021 - nature.com
Pancreatic cancer is a leading cause of cancer death worldwide and its global burden has
more than doubled over the past 25 years. The highest incidence regions for pancreatic …

Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives

S Wang, Y Zheng, F Yang, L Zhu, XQ Zhu… - Signal transduction and …, 2021 - nature.com
Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Early screening and diagnosis strategies of pancreatic cancer: a comprehensive review

J Yang, R Xu, C Wang, J Qiu, B Ren… - Cancer …, 2021 - Wiley Online Library
Pancreatic cancer is a highly malignant digestive system tumor with a poor prognosis. Most
pancreatic cancer patients are diagnosed at an advanced stage or even metastasis due to …

[HTML][HTML] Multi-omics approaches in cancer research with applications in tumor subtyping, prognosis, and diagnosis

O Menyhárt, B Győrffy - Computational and structural biotechnology journal, 2021 - Elsevier
While cost-effective high-throughput technologies provide an increasing amount of data, the
analyses of single layers of data seldom provide causal relations. Multi-omics data …

Lead-time trajectory of CA19-9 as an anchor marker for pancreatic cancer early detection

JF Fahrmann, CM Schmidt, X Mao, E Irajizad, M Loftus… - Gastroenterology, 2021 - Elsevier
Background & Aims There is substantial interest in liquid biopsy approaches for cancer early
detection among subjects at risk, using multi-marker panels. CA19-9 is an established …

Early detection of pancreatic cancer using DNA-based molecular approaches

AD Singhi, LD Wood - Nature Reviews Gastroenterology & Hepatology, 2021 - nature.com
Due to its poor prognosis and the late stage at which it is typically diagnosed, early detection
of pancreatic cancer is a pressing clinical problem. Advances in genomic analysis of human …

Blueprint for cancer research: critical gaps and opportunities

LW Elmore, SF Greer, EC Daniels… - CA: A Cancer …, 2021 - Wiley Online Library
We are experiencing a revolution in cancer. Advances in screening, targeted and immune
therapies, big data, computational methodologies, and significant new knowledge of cancer …

Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications

H Hu, Z Ye, Y Qin, X Xu, X Yu, Q Zhuo… - Acta Pharmacologica …, 2021 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with a minimal
difference between its incidence rate and mortality rate. Advances in oncology over the past …

High-throughput proteomics and AI for cancer biomarker discovery

Q Xiao, F Zhang, L Xu, L Yue, OL Kon, Y Zhu… - Advanced drug delivery …, 2021 - Elsevier
Biomarkers are assayed to assess biological and pathological status. Recent advances in
high-throughput proteomic technology provide opportunities for developing next generation …