While the existence of a special relationship between Mycobacterium tuberculosis (Mtb) and
host lipids has long been known, it remains a challenging enigma. It was clearly established …

Lactosylceramide (LacCer), also known as CD17/CDw17, is a member of a large family of
small molecular weight compounds known as glycosphingolipids. It plays a pivotal role in …

Acidic pH arrests the growth of Mycobacterium tuberculosis in vitro (pH< 5.8) and is thought
to significantly contribute to the ability of macrophages to control M. tuberculosis replication …

Because disease-associated microglia (DAM) and disease-associated astrocytes (DAA) are
involved in the pathophysiology of Alzheimer's disease (AD), we systematically identified …

The appearance and rapid spread of drug resistant strains of tuberculosis (TB), one of the
deadliest infectious diseases, pose a serious threat to public health and increase the need …

In the ongoing conflict between eukaryotic cells and pathogens, lipid droplets (LDs) emerge
as a choke point in the battle for nutrients. While many pathogens seek the lipids stored in …

In the face of ineffective vaccines, increasing antibiotic resistance and the decline in new
antibacterial drugs in the pipeline, tuberculosis (TB) still remains pandemic. Exposure to …

Lengthy multidrug chemotherapy is required to achieve a durable cure in tuberculosis.
However, we lack well-validated, high-throughput in vitro models that predict animal …

Mycobacterium tuberculosis infects primarily macrophages in the lungs. Infected
macrophages are surrounded by other immune cells in well organised structures called …

Encapsulin nanocompartments are an emerging class of prokaryotic protein-based
organelle consisting of an encapsulin protein shell that encloses a protein cargo. Genes …