Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics
Decades of neurobiological research have disclosed the diverse manners in which the
response properties of neurons are dynamically modulated to support adaptive cognitive …
response properties of neurons are dynamically modulated to support adaptive cognitive …
[HTML][HTML] The locus coeruleus-norepinephrine system in stress and arousal: unraveling historical, current, and future perspectives
JA Ross, EJ Van Bockstaele - Frontiers in psychiatry, 2021 - frontiersin.org
Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction,
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and …
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and …
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline
Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …
[HTML][HTML] Noradrenergic circuit control of non-REM sleep substates
To understand what makes sleep vulnerable in disease, it is useful to look at how wake-
promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity is inhibited …
promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity is inhibited …
[HTML][HTML] What have we really learned from functional connectivity in clinical populations?
Functional connectivity (FC), or the statistical interdependence of blood-oxygen dependent
level (BOLD) signals between brain regions using fMRI, has emerged as a widely used tool …
level (BOLD) signals between brain regions using fMRI, has emerged as a widely used tool …
[HTML][HTML] Locus coeruleus norepinephrine in learned behavior: anatomical modularity and spatiotemporal integration in targets
V Breton-Provencher, GT Drummond… - Frontiers in Neural …, 2021 - frontiersin.org
The locus coeruleus (LC), a small brainstem nucleus, is the primary source of the
neuromodulator norepinephrine (NE) in the brain. The LC receives input from widespread …
neuromodulator norepinephrine (NE) in the brain. The LC receives input from widespread …
Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson's disease
Cognitive decline is a common feature of Parkinson's disease, and many of these cognitive
deficits fail to respond to dopaminergic therapy. Therefore, targeting other neuromodulatory …
deficits fail to respond to dopaminergic therapy. Therefore, targeting other neuromodulatory …
Association of locus coeruleus and substantia nigra pathology with cognitive and motor functions in patients with Parkinson disease
J Prasuhn, M Prasuhn, A Fellbrich, R Strautz… - Neurology, 2021 - AAN Enterprises
Objective To investigate the contribution of substantia nigra (SN) and locus coeruleus (LC)
pathology to clinical signs and symptoms in Parkinson disease (PD) by applying …
pathology to clinical signs and symptoms in Parkinson disease (PD) by applying …
Out-of-step: brain-heart desynchronization in anxiety disorders
Imaging studies in anxiety disorders (AD) show abnormal functional connectivity primarily in
the salience network (SN), somatomotor network (SMN), and default mode network (DMN) …
the salience network (SN), somatomotor network (SMN), and default mode network (DMN) …
[HTML][HTML] Propagating patterns of intrinsic activity along macroscale gradients coordinate functional connections across the whole brain
B Yousefi, S Keilholz - NeuroImage, 2021 - Elsevier
The intrinsic activity of the human brain, observed with resting-state fMRI (rsfMRI) and
functional connectivity, exhibits macroscale spatial organization such as functional networks …
functional connectivity, exhibits macroscale spatial organization such as functional networks …