Bone is a multi-skilled tissue, protecting major organs, regulating calcium phosphate
balance and producing hormones. Its development during childhood determines height and …

The complex multidimensional skeletal organization can adapt its structure in accordance
with external contexts, demonstrating excellent self-renewal capacity. Thus, optimal …

Background Rapid, non-genomic estrogen receptor (ER) signaling plays an integral role in
mediating the tissue selective properties of ER modulators. Icariin, a bone bioactive …

Microstructural adaptation of bone in response to mechanical stimuli is diminished with
estrogen deprivation. Here we tested in vivo whether ovariectomy (OVX) alters the acute …

Biomechanical stimulation by whole-body low-magnitude high-frequency vibration (LMHFV)
has demonstrated to provoke anabolic effects on bone metabolism in both non-osteoporotic …

Estrogen receptor-α knockout (ERKO) in female, but not male, mice results in an impaired
osteogenic response to exercise, but the mechanisms behind this ability in males are …

Estrogen levels decline in both sexes with age, but more dramatically in females. Activation
of the Wnt/β-catenin signaling pathway is central to the regulation of bone mass accrual and …

Mechanical stress determines bone mass and structure. It is not known whether mechanical
loading affects expression of bone regulatory genes in a combined deficiency of estrogen …

Osteosarcoma is a highly malignant musculoskeletal tumor that is commonly noticed in
adolescent children, young children, and elderly adults. Due to advances in surgery …

Male gender is a protective factor against the development of osteoporosis but men face a
higher refracture risk, higher mortality risk, and a higher treatment gap. Consequently, men …