DNA methylation signatures of incident coronary heart disease: findings from epigenome-wide association studies

Y Xia, A Brewer, JT Bell - Clinical Epigenetics, 2021 - Springer
Coronary heart disease (CHD) is a type of cardiovascular disease (CVD) that affects the
coronary arteries, which provide oxygenated blood to the heart. It is a major cause of …

Epigenome-wide analysis of DNA methylation and coronary heart disease: a nested case-control study

J Si, S Yang, D Sun, C Yu, Y Guo, Y Lin, IY Millwood… - Elife, 2021 - elifesciences.org
Background: Identifying environmentally responsive genetic loci where DNA methylation is
associated with coronary heart disease (CHD) may reveal novel pathways or therapeutic …

[HTML][HTML] 多组学在慢性病病因学研究中的应用及其进展

庞元捷, 吕筠, 余灿清, 李立明 - 中华流行病学杂志, 2021 - html.rhhz.net
慢性病流行病学的主要目的之一是探索疾病病因. 多组学通常包括在脱氧核糖核酸复制, 转录,
翻译, 翻译后修饰的过程中, 产生的全部基因(基因组学), 基因表达的广泛变化(表观遗传组学) …

[HTML][HTML] Psycho-cardiology therapeutic effects of Shuangxinfang in rats with depression-behavior post acute myocardial infarction: focus on protein S100A9 from …

Y Sun, Z Wang, C Wang, Z Tang, H Zhao - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Background Depressive disorders induced by acute myocardial infarction (AMI) play a
pivotal role in the deterioration of cardiac function, and Shuangxinfang (Psycho-cardiology …

Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome

P Long, Q Wang, Y Zhang, X Zhu, K Yu, H Jiang… - Clinical …, 2021 - Springer
Background Acute coronary syndrome (ACS) is a cardiac emergency with high mortality.
Exposure to high copper (Cu) concentration has been linked to ACS. However, whether …

Comprehensive analysis of mRNA expression profiling and identification of potential diagnostic biomarkers in coronary artery disease

JX Chen, S He, YJ Wang, XK Gan, YQ Zhou, L Hua… - ACS …, 2021 - ACS Publications
The aim of this study is to investigate mRNA expression profiling by RNA sequencing (RNA-
seq) in patients with coronary artery disease (CAD) and validate differentially expressed …

The methylation of the AMER3 gene mediates the negative association between urinary polycyclic aromatic hydrocarbon metabolites and fasting plasma glucose in …

X Nie, G Mu, S Yang, Z Ye, M Wang, D Wang… - Journal of Hazardous …, 2021 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) have been reported to cause various health
damages. However, some PAH derivatives are still used as agents, and some of them have …

Epigenome-wide association study and network analysis for IgA Nephropathy from CD19+ B-cell in Chinese Population

Y Lin, P Yin, Z Zhu, Y Peng, M Li, J Li, L Liang, X Yu - Epigenetics, 2021 - Taylor & Francis
IgA nephropathy (IgAN) is the most common primary glomerular disease in China and
worldwide. The proliferation of B cells is known to be associated with both risk and …

Genome-wide analysis of DNA methylation and risk of cardiovascular disease in a Chinese population

Y Gao, H Pang, B Chen, CQ Wu, Y Wang, L Hou… - BMC Cardiovascular …, 2021 - Springer
Background Systemic studies of association of genome-wide DNA methylated sites with
cardiovascular disease (CVD) in prospective cohorts are lacking. Our aim was to identify …

Androgen receptor DNA methylation is an independent determinant of glucose metabolic disorders in women; testosterone plays a moderating effect

X Liu, W Huo, R Zhang, D Wei, R Tu, Z Luo… - Journal of …, 2021 - Wiley Online Library
Background We have previously shown that serum testosterone was associated with
impaired fasting glucose (IFG) and type 2 diabetes (T2D). Testosterone can be acting …