Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in
regulating gene expression. The epigenetic component is strongly involved in aging-bone …

The rising incidence of bone pathologies such as osteoporosis and osteoarthritis is
negatively affecting the functional status of millions of patients worldwide. The genetic …

Difficulty in obtaining bone tissue is an obstacle to studying epigenetics to understand gene–
environment interactions, and their role in disease pathogenesis. Blood is an obvious …

Epigenetic mechanisms may contribute to idiopathic scoliosis (IS). We identified 8
monozygotic twin pairs with IS, 6 discordant (Cobb angle difference> 10°) and 2 concordant …

Epigenetic factors, such as DNA methylation, play an influential role in the development of
the degenerative joint disease osteoarthritis (OA). These molecular mechanisms have been …

Crossed beaks have been observed in at least 12 chicken strains around the world, which
severely impairs their growth and welfare. To explore the intrinsic factor causing crossed …

Mesenchymal stem cells (MSCs) are progenitors of connective tissues, which have emerged
as important tools for tissue engineering owing to their differentiation potential in various cell …