Anticancer drugs are a group of therapeutic agents used to enhance cell death in targeted
cell types of neoplasia. Because of frequent use and eventual discharge, they have been …

Abstract With the European Union's restrictions on toxicity tests using vertebrates and the
issue of the Organization for Economic Co-operation and Development test guideline 236 …

Dimethyl sulfoxide (DMSO) is a popular solvent for developmental toxicity testing of
chemicals and pharmaceuticals in zebrafish embryos. In general, it is recommended to keep …

Polybrominated diphenyl ethers (PBDEs) are a class of widely used flame retardants, and
their residue in the environment may threaten the ecosystem and human health. The …

The zebrafish as an alternative animal model for developmental toxicity testing has been
extensively investigated, but its assay protocol was not harmonized yet. This study has …

A wide array of pathogens has the potential to injure the fetus and induce teratogenesis, the
process by which mutations in fetal somatic cells lead to congenital malformations. Rubella …

Caffeine (CAF), a neuroactive compound, has been found in surface waters at
concentrations ranging from few nanograms up to micrograms and may induce adverse …

EFSA is implementing evidence‐based risk assessments for the re‐evaluation of certain
sweeteners. The aim of this work was to ensure that, as part of the preparatory work done by …

Abstract Ethnopharmacological relevance Clerodendrum cyrtophyllum Turcz has been used
in traditional medicine for the treatment of various diseases. In spite of its therapeutic …

The zebrafish (Danio rerio) embryo is gaining interest as a bridging tool between in-vitro and
in-vivo developmental toxicity studies. However, cytochrome P450 (CYP)-mediated drug …