Istradefylline – a first generation adenosine A2A antagonist for the treatment of Parkinson's disease
P Jenner, A Mori, SD Aradi… - Expert Review of …, 2021 - Taylor & Francis
Introduction It is now accepted that Parkinson's disease (PD) is not simply due to
dopaminergic dysfunction, and there is interest in developing non-dopaminergic …
dopaminergic dysfunction, and there is interest in developing non-dopaminergic …
Modulation of NMDA receptors by G-protein-coupled receptors: role in synaptic transmission, plasticity and beyond
S Lutzu, PE Castillo - Neuroscience, 2021 - Elsevier
NMDA receptors (NMDARs) play a critical role in excitatory synaptic transmission, plasticity
and in several forms of learning and memory. In addition, NMDAR dysfunction is believed to …
and in several forms of learning and memory. In addition, NMDAR dysfunction is believed to …
The pathophysiology and treatment of essential tremor: the role of adenosine and dopamine receptors in animal models
B Kosmowska, J Wardas - Biomolecules, 2021 - mdpi.com
Essential tremor (ET) is one of the most common neurological disorders that often affects
people in the prime of their lives, leading to a significant reduction in their quality of life …
people in the prime of their lives, leading to a significant reduction in their quality of life …
Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and …
K Prasad, EFJ de Vries, PH Elsinga… - International Journal of …, 2021 - mdpi.com
Adenosine and dopamine interact antagonistically in living mammals. These interactions are
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …
Development of Covalent, Clickable Probes for Adenosine A1 and A3 Receptors
Adenosine receptors are attractive therapeutic targets for multiple conditions, including
ischemia-reperfusion injury and neuropathic pain. Adenosine receptor drug discovery efforts …
ischemia-reperfusion injury and neuropathic pain. Adenosine receptor drug discovery efforts …
A2A receptor dysregulation in dystonia DYT1 knock-out mice
We aimed to investigate A2A receptors in the basal ganglia of a DYT1 mouse model of
dystonia. A2A was studied in control Tor1a+/+ and Tor1a+/− knock-out mice. A2A …
dystonia. A2A was studied in control Tor1a+/+ and Tor1a+/− knock-out mice. A2A …
A novel method for detecting heteromeric complexes at synaptic level by combining a modified method of proximity ligation assay with transmission electron …
SW Tan, P Li, YL Ning, Y Zhao, N Yang… - Neurochemistry …, 2021 - Elsevier
The heteromeric complexes of adenosine 2A receptor (A2AR) and N-methyl-D-aspartate
receptor (NMDAR) have recently been confirmed in cell experiments, while its in situ …
receptor (NMDAR) have recently been confirmed in cell experiments, while its in situ …
New insight into the role of adenosine and acetylcholine receptors on neuronal excitability and oligodendrogliogenesis: an in vitro study
F Cherchi - 2021 - flore.unifi.it
In the CNS, acetylcholine (ACh) is a key neurotransmitter implicated in higher brain
functions, including cognitive processes. The Nucleus Basalis of Meynert (NBM) is the major …
functions, including cognitive processes. The Nucleus Basalis of Meynert (NBM) is the major …
[PDF][PDF] Evaluación de la unión a los receptores de adenosina A1 y A2A en la corteza cerebral de pacientes con epilepsia del lóbulo frontal y la influencia de la edad
M Fuentes Mejia - 2021 - repositorio.cinvestav.mx
La adenosina es un nucleósido de purina endógeno, formado por una adenina unida por
un enlace β-N glucosídico a una ribosa (Figura 1). Es importante en el metabolismo …
un enlace β-N glucosídico a una ribosa (Figura 1). Es importante en el metabolismo …