Cardiac fibrosis

NG Frangogiannis - Cardiovascular research, 2021 - academic.oup.com
Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

COVID-19 myocarditis and prospective heart failure burden

A Shchendrygina, E Nagel, VO Puntmann… - Expert review of …, 2021 - Taylor & Francis
Introduction: COVID-19 is causing considerable morbidity and mortality worldwide. Serious
respiratory complications aside, the heart is also frequently involved. The mechanisms and …

Empagliflozin ameliorates diastolic dysfunction and left ventricular fibrosis/stiffness in nondiabetic heart failure: a multimodality study

CG Santos-Gallego, JA Requena-Ibanez… - Cardiovascular …, 2021 - jacc.org
Objectives The purpose of this study was to investigate the effect of empagliflozin on
diastolic function in a nondiabetic heart failure with reduced ejection fraction (HFrEF) …

Effect of neprilysin inhibition on left ventricular remodeling in patients with asymptomatic left ventricular systolic dysfunction late after myocardial infarction

KF Docherty, RT Campbell, KJM Brooksbank… - Circulation, 2021 - Am Heart Assoc
Background: Patients with left ventricular (LV) systolic dysfunction after myocardial infarction
are at a high risk of developing heart failure. The addition of neprilysin inhibition to renin …

Prognostic value of myocardial extracellular volume fraction evaluation based on cardiac magnetic resonance T1 mapping with T1 long and short in hypertrophic …

Y Li, X Liu, F Yang, J Wang, Y Xu, TT Fang, LT Pu… - European …, 2021 - Springer
Objective To investigate the prognostic significance of T1 mapping using T1 long and short
in hypertrophic cardiomyopathy (HCM) patients. Methods A total of 263 consecutive patients …

[HTML][HTML] Myocardial T1-mapping and extracellular volume in pulmonary arterial hypertension: A systematic review and meta-analysis

S Alabed, L Saunders, P Garg, Y Shahin… - Magnetic resonance …, 2021 - Elsevier
Introduction Elevated myocardial T 1-mapping and extracellular volume (ECV) measured on
cardiac MR (CMR) imaging is associated with myocardial abnormalities such as oedema or …

Cardiovascular outcomes in systemic sclerosis with abnormal cardiovascular MRI and serum cardiac biomarkers

RB Dumitru, LA Bissell, B Erhayiem, A Kidambi… - RMD open, 2021 - rmdopen.bmj.com
Objectives To explore the prognostic value of subclinical cardiovascular (CV) imaging
measures and serum cardiac biomarkers in systemic sclerosis (SSc) for the development of …

Predictors of subclinical systemic sclerosis primary heart involvement characterised by microvasculopathy and myocardial fibrosis

RB Dumitru, LA Bissell, B Erhayiem, G Fent… - …, 2021 - academic.oup.com
Objectives SSc primary heart involvement (SSc-pHI) is a significant cause of mortality. We
aimed to characterize and identify predictors of subclinical SSc-pHI using cardiovascular …

Collagen‐Targeted Peptides for Molecular Imaging of Diffuse Cardiac Fibrosis

M Ezeani, A Noor, K Alt, S Lal, PS Donnelly… - Journal of the …, 2021 - Am Heart Assoc
Background Cardiac fibrosis is the excessive deposition of extracellular matrix in the heart,
triggered by a cardiac insult, aging, genetics, or environmental factors. Molecular imaging of …

[HTML][HTML] The association of reduced left ventricular strains with increased extracellular volume and their collective impact on clinical outcomes

C Jin, J Weber, H Singh, K Gliganic, JJ Cao - Journal of Cardiovascular …, 2021 - Elsevier
Background Myocardial fibrosis and left ventricular (LV) longitudinal strain are
independently associated with adverse clinical outcomes. However, the relationship …