Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
Autophagy in metabolic disease and ageing
M Kitada, D Koya - Nature Reviews Endocrinology, 2021 - nature.com
Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …
cytoplasmic components, including damaged organelles, protein aggregates and lipid …
[HTML][HTML] SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …
Mechanisms of selective autophagy
T Lamark, T Johansen - Annual review of cell and …, 2021 - annualreviews.org
Selective autophagy is the lysosomal degradation of specific intracellular components
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …
Organelle-specific regulation of ferroptosis
Ferroptosis, a cell death modality characterized by iron-dependent lipid peroxidation, is
involved in the development of multiple pathological conditions, including ischemic tissue …
involved in the development of multiple pathological conditions, including ischemic tissue …
[PDF][PDF] ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation
G Miao, H Zhao, Y Li, M Ji, Y Chen, Y Shi, Y Bi… - Developmental cell, 2021 - cell.com
Autophagy acts as a cellular surveillance mechanism to combat invading pathogens.
Viruses have evolved various strategies to block autophagy and even subvert it for their …
Viruses have evolved various strategies to block autophagy and even subvert it for their …
Quantum computer based on color centers in diamond
S Pezzagna, J Meijer - Applied Physics Reviews, 2021 - pubs.aip.org
Artificial atoms like the nitrogen vacancy (NV) centers in diamond enable the realization of
fully functional qubits in a solid at room temperature. The functionalities of all the parts …
fully functional qubits in a solid at room temperature. The functionalities of all the parts …
[HTML][HTML] The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes
Y Zhang, H Sun, R Pei, B Mao, Z Zhao, H Li, Y Lin, K Lu - Cell discovery, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing
coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to …
coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to …
[HTML][HTML] The STING1 network regulates autophagy and cell death
Cell death and immune response are at the core of life. In past decades, the endoplasmic
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …
[HTML][HTML] N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells
M Shen, Y Li, Y Wang, J Shao, F Zhang, G Yin, A Chen… - Redox Biology, 2021 - Elsevier
Ferroptosis is a recently identified non-apoptotic form of cell death characterized by iron-
dependent lipid peroxidation. However, the underlying exact mechanisms remain poorly …
dependent lipid peroxidation. However, the underlying exact mechanisms remain poorly …