Novel therapeutic approaches for Alzheimer's disease: an updated review

TW Yu, HY Lane, CH Lin - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease and accounts for
most cases of dementia. The prevalence of AD has increased in the current rapidly aging …

A review of parameter settings for invasive and non-invasive vagus nerve stimulation (VNS) applied in neurological and psychiatric disorders

SL Thompson, GH O'Leary, CW Austelle… - Frontiers in …, 2021 - frontiersin.org
Vagus nerve stimulation (VNS) is an established form of neuromodulation with a long history
of promising applications. Earliest reports of VNS in the literature date to the late 1800's in …

Does transcutaneous auricular vagus nerve stimulation affect vagally mediated heart rate variability? A living and interactive Bayesian meta‐analysis

V Wolf, A Kühnel, V Teckentrup, J Koenig… - …, 2021 - Wiley Online Library
Non‐invasive brain stimulation techniques, such as transcutaneous auricular vagus nerve
stimulation (taVNS), have considerable potential for clinical use. Beneficial effects of taVNS …

Stress and aging: A neurovisceral integration perspective

JF Thayer, M Mather, J Koenig - Psychophysiology, 2021 - Wiley Online Library
Darwin emphasized the intimate relationship between the brain and the heart over 150
years ago. Healthy aging is associated with significant changes in both the brain and the …

The effects of transcutaneous auricular vagal nerve stimulation on cognition in healthy individuals: A meta-analysis.

C Ridgewell, KJ Heaton, A Hildebrandt, J Couse… - …, 2021 - psycnet.apa.org
Objective: Transcutaneous auricular vagal nerve stimulation (taVNS) may benefit cognition
in healthy adults but may differentially affect specific domains of cognitive function. Currently …

current and future treatment approaches for pain in IBS

P Paine - Alimentary Pharmacology & Therapeutics, 2021 - Wiley Online Library
Background Abdominal pain is a core symptom of IBS and a primary driver of care seeking.
Visceral hypersensitivity is a key pathophysiological mechanism and therapeutic target for …

Effects of transcutaneous auricular vagus nerve stimulation on reversal learning, tonic pupil size, salivary alpha‐amylase, and cortisol

M D'Agostini, AM Burger, M Franssen… - …, 2021 - Wiley Online Library
This study investigated whether transcutaneous auricular vagus nerve stimulation (taVNS)
enhances reversal learning and augments noradrenergic biomarkers (ie, pupil size, cortisol …

Auricular vagus neuromodulation—a systematic review on quality of evidence and clinical effects

N Verma, JD Mudge, M Kasole, RC Chen… - Frontiers in …, 2021 - frontiersin.org
Background: The auricular branch of the vagus nerve runs superficially, which makes it a
favorable target for non-invasive stimulation techniques to modulate vagal activity. For this …

Noninvasive vagus nerve stimulation in Parkinson's disease: current status and future prospects

HP Sigurdsson, R Raw, H Hunter… - Expert Review of …, 2021 - Taylor & Francis
Introduction Parkinson's disease (PD) is a common progressive neurodegenerative disorder
with multifactorial etiology. While dopaminergic medication is the standard therapy in PD, it …

Transdermal auricular vagus stimulation for the treatment of postural tachycardia syndrome

A Diedrich, V Urechie, D Shiffer, S Rigo… - Autonomic …, 2021 - Elsevier
Abstract Postural Tachycardia Syndrome (POTS) is a chronic disorder characterized by
symptoms of orthostatic intolerance such as fatigue, lightheadedness, dizziness …