The immune system has crucial roles in cancer development and treatment. Whereas
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …

Background Optimal antiplatelet monotherapy during the chronic maintenance period in
patients who undergo coronary stenting is unknown. We aimed to compare head to head the …

Given rapid advancements in medical science, it is often challenging for the busy clinician to
remain up-to-date on the fundamental and multifaceted aspects of preventive cardiology and …

Patients with inflammatory bowel disease (IBD) are at increased risk of thrombotic events.
Therapies for IBD have the potential to modulate this risk. The aims of this Evidence-Based …

Diabetes (type 2) and sensorineural hearing loss are common health problems manifested
with ageing. While both type 1 and type 2 diabetes have been associated with hearing loss …

Drug repurposing is promoted as a cost-and time-effective mechanism for providing new
medicines. Often, however, there is insufficient consideration by academic researchers of …

'Covert'cerebral small vessel disease (ccSVD) is common on neuroimaging in persons
without overt neurological manifestations, and increases the risk of future stroke, cognitive …

Background & Aims DNA mismatch repair deficiency drives microsatellite instability (MSI).
Cells with MSI accumulate numerous frameshift mutations. Frameshift mutations affecting …

Abstract Background ASPirin in Reducing Events in the Elderly, a randomized, double-blind,
placebo-controlled trial of daily low-dose aspirin (100 mg) in older adults, showed an …