[HTML][HTML] Aquaporins have regional functions in development of refractive index in the zebrafish eye lens
K Wang, I Vorontsova, M Hoshino… - … & Visual Science, 2021 - jov.arvojournals.org
Purpose: In the eye lens, cytosolic protein concentrations increase progressively from the
periphery to the center, contributing to the gradient of refractive index (GRIN). Aquaporins …
periphery to the center, contributing to the gradient of refractive index (GRIN). Aquaporins …
[HTML][HTML] Spatially resolved proteomic analysis of the lens extracellular diffusion barrier
Z Wang, LS Cantrell, KL Schey - … Ophthalmology & Visual …, 2021 - iovs.arvojournals.org
Purpose: The presence of a physical barrier to molecular diffusion through lenticular
extracellular space has been repeatedly detected. This extracellular diffusion barrier has …
extracellular space has been repeatedly detected. This extracellular diffusion barrier has …
Deletion of beaded filament proteins or the C-terminal end of Aquaporin 0 causes analogous abnormal distortion aberrations in mouse lens
K Varadaraj, PG FitzGerald, SS Kumari - Experimental eye research, 2021 - Elsevier
Lens-specific beaded filament (BF) proteins CP49 and filensin interact with the C-terminus of
the water channel protein Aquaporin 0 (AQP0). Previously we have reported that a C …
the water channel protein Aquaporin 0 (AQP0). Previously we have reported that a C …
[HTML][HTML] Differences in a single extracellular residue underlie adhesive functions of two zebrafish Aqp0s
I Vorontsova, JE Hall, TF Schilling, N Nagai… - Cells, 2021 - mdpi.com
Aquaporin 0 (AQP0) is the most abundant lens membrane protein, and loss of function in
human and animal models leads to cataract formation. AQP0 has several functions in the …
human and animal models leads to cataract formation. AQP0 has several functions in the …
[HTML][HTML] A novel missense mutation in the gene encoding major intrinsic protein (MIP) in a Giant panda with unilateral cataract formation
C Bai, Y You, X Liu, M Xia, W Wang, T Jia, T Pu, Y Lu… - BMC genomics, 2021 - Springer
Background Cataracts are defects of the lens that cause progressive visual impairment and
ultimately blindness in many vertebrate species. Most cataracts are age-related, but up to …
ultimately blindness in many vertebrate species. Most cataracts are age-related, but up to …
[HTML][HTML] Anti-cataract therapies: is there a need for a new approach based on targeting of aquaporins?
BK Pierscionek - Expert Opinion on Therapeutic Targets, 2021 - Taylor & Francis
A quote attributed to Leonardo da Vinci that 'Simplicity is the ultimate sophistication'can be
applied to the elegant yet relatively simple structure of the eye lens which, devoid of blood …
applied to the elegant yet relatively simple structure of the eye lens which, devoid of blood …
Deletion of beaded filament proteins or the C-terminal end of Aquaporin 0 causes analogous abnormal distortion aberrations in mouse lens
K Varadaraj, PG FitzGerald, SS Kumari - 2021 - escholarship.org
Lens-specific beaded filament (BF) proteins CP49 and filensin interact with the C-terminus of
the water channel protein Aquaporin 0 (AQP0). Previously we have reported that a C …
the water channel protein Aquaporin 0 (AQP0). Previously we have reported that a C …