[HTML][HTML] PI3K inhibitors in cancer: clinical implications and adverse effects
The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …
How can we turn the PI3K/AKT/mTOR pathway down? Insights into inhibition and treatment of cancer
ABSTRACT Introduction: The phosphatidylinositol 3-kinase/protein kinase-B/mammalian
target of rapamycin (PI3K/AKT/mTOR) pathway is a fundamental regulator of cell …
target of rapamycin (PI3K/AKT/mTOR) pathway is a fundamental regulator of cell …
[HTML][HTML] Targeting SHIP1 and SHIP2 in Cancer
Simple Summary Phosphoinositol signaling pathways and their dysregulation have been
shown to have a fundamental role in health and disease, respectively. The SH2-containing …
shown to have a fundamental role in health and disease, respectively. The SH2-containing …
AKT1 and PTEN show the highest affinities among phosphoinositide binding proteins for the second messengers PtdIns (3, 4, 5) P3 and PtdIns (3, 4) P2
N Nelson, A Razeto, A Gilardi, M Grättinger… - Biochemical and …, 2021 - Elsevier
Abstract The phosphoinositides phosphatidylinositol-3, 4, 5-trisphosphate [PtdIns (3, 4, 5) P
3] and phosphatidylinositol-3, 4-bisphosphate [PtdIns (3, 4) P 2] function as second …
3] and phosphatidylinositol-3, 4-bisphosphate [PtdIns (3, 4) P 2] function as second …
Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies
YS Kim, MG Cheon, PR Boggu, SY Koh… - Bioorganic & Medicinal …, 2021 - Elsevier
Abstract Phosphatidylinositol 3-kinases (PI3Ks) mediate intracellular signal transduction.
Aberrant PI3K signaling is associated with oncogenesis and disease progression in solid …
Aberrant PI3K signaling is associated with oncogenesis and disease progression in solid …
Discovery of Eucalyptin C, derived from the fruits of Eucalyptus globulus Labill., as a novel selective PI3Kγ inhibitor for immunosuppressive treatment
HU Xiao-Long, S Wei, W Rong, L Huan, W Quan… - Chinese Journal of …, 2021 - Elsevier
The fruits of Eucalyptus globulus Labill. are known to have a plenty of medicinal properties,
such as anti-tumor, anti-inflammatory, and immunosuppressive activity. Our previous study …
such as anti-tumor, anti-inflammatory, and immunosuppressive activity. Our previous study …
Discovery of GSK251: a highly potent, highly selective, orally bioavailable inhibitor of PI3Kδ with a novel binding mode
Optimization of a previously reported lead series of PI3Kδ inhibitors with a novel binding
mode led to the identification of a clinical candidate compound 31 (GSK251). Removal of an …
mode led to the identification of a clinical candidate compound 31 (GSK251). Removal of an …
[PDF][PDF] The Functional Interplay Between PTEN and PDK1 in Acute Leukemia
SY Zhang - 2021 - kclpure.kcl.ac.uk
Considered one of the frequently deregulated pathways in leukemia, the PI3K/AKT pathway
is a highly conserved signal transduction pathway associated with cell growth, survival, and …
is a highly conserved signal transduction pathway associated with cell growth, survival, and …