[HTML][HTML] N6-methyladenosine methyltransferases: functions, regulation, and clinical potential
W Huang, TQ Chen, K Fang, ZC Zeng, H Ye… - Journal of Hematology & …, 2021 - Springer
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …
[HTML][HTML] The WNT/ROR pathway in cancer: from signaling to therapeutic intervention
K Menck, S Heinrichs, C Baden, A Bleckmann - Cells, 2021 - mdpi.com
The WNT pathway is one of the major signaling cascades frequently deregulated in human
cancer. While research had initially focused on signal transduction centered on β-catenin as …
cancer. While research had initially focused on signal transduction centered on β-catenin as …
[HTML][HTML] A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver
D Inverso, J Shi, KH Lee, M Jakab, S Ben-Moshe… - Developmental cell, 2021 - cell.com
Single-cell transcriptomics (scRNA-seq) has revolutionized the understanding of the spatial
architecture of tissue structure and function. Advancing the" transcript-centric" view of scRNA …
architecture of tissue structure and function. Advancing the" transcript-centric" view of scRNA …
SOX9: An emerging driving factor from cancer progression to drug resistance
Dysregulation of transcription factors is one of the common problems in the pathogenesis of
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …
[HTML][HTML] LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway
M Tan, Y Cheng, X Zhong, D Yang, S Jiang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Background: Polycystic ovary syndrome (PCOS), which is often accompanied by insulin
resistance, is closely related to increased apoptosis of ovarian granulosa cells. LNK is an …
resistance, is closely related to increased apoptosis of ovarian granulosa cells. LNK is an …
[HTML][HTML] H2S exposure induces cell death in the broiler thymus via the ROS-initiated JNK/MST1/FOXO1 pathway
Q Chi, X Hu, Z Liu, Y Han, D Tao, S Xu, S Li - … and Environmental Safety, 2021 - Elsevier
Hydrogen sulfide (H 2 S) is a common toxic gas in chicken houses that endangers the health
of poultry. Harbin has a cold climate in winter, and the conflict between heat preservation …
of poultry. Harbin has a cold climate in winter, and the conflict between heat preservation …
[HTML][HTML] FOXO3a and its regulators in prostate cancer
DE Habrowska-Górczyńska, MJ Kozieł… - International Journal of …, 2021 - mdpi.com
Forkhead box O3 (FOXO3a) is a member of a subfamily of forkhead transcription factors
involved in the basic processes within a cell, including proliferation, apoptosis, cell cycle …
involved in the basic processes within a cell, including proliferation, apoptosis, cell cycle …
Role of iron and iron‐related proteins in mesenchymal stem cells: cellular and clinical aspects
KJ Mehta - Journal of cellular physiology, 2021 - Wiley Online Library
Mesenchymal stem cells (MSCs) are located in various tissues where these cells show
niche‐dependent multilineage differentiation and secrete immunomodulatory molecules to …
niche‐dependent multilineage differentiation and secrete immunomodulatory molecules to …
[HTML][HTML] Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade
ADR Nurcahyanti, A Jap, J Lady, D Prismawan… - Biomedicine & …, 2021 - Elsevier
Diabetes mellitus (DM) is a metabolic disorder with growing global incidence, as 387 million
people were diagnosed in 2014 with an expected projection of 642 million in 2040. Several …
people were diagnosed in 2014 with an expected projection of 642 million in 2040. Several …
[HTML][HTML] Regulation of Wnt signaling by FOX transcription factors in cancer
S Koch - Cancers, 2021 - mdpi.com
Simple Summary Cancer is caused by a breakdown of cell-to-cell communication, which
results in the unrestricted expansion of cells within a tissue. In many cases, tumor growth is …
results in the unrestricted expansion of cells within a tissue. In many cases, tumor growth is …