[HTML][HTML] N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

W Huang, TQ Chen, K Fang, ZC Zeng, H Ye… - Journal of Hematology & …, 2021 - Springer
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …

[HTML][HTML] The WNT/ROR pathway in cancer: from signaling to therapeutic intervention

K Menck, S Heinrichs, C Baden, A Bleckmann - Cells, 2021 - mdpi.com
The WNT pathway is one of the major signaling cascades frequently deregulated in human
cancer. While research had initially focused on signal transduction centered on β-catenin as …

[HTML][HTML] A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver

D Inverso, J Shi, KH Lee, M Jakab, S Ben-Moshe… - Developmental cell, 2021 - cell.com
Single-cell transcriptomics (scRNA-seq) has revolutionized the understanding of the spatial
architecture of tissue structure and function. Advancing the" transcript-centric" view of scRNA …

SOX9: An emerging driving factor from cancer progression to drug resistance

M Panda, SK Tripathi, BK Biswal - … et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
Dysregulation of transcription factors is one of the common problems in the pathogenesis of
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …

[HTML][HTML] LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway

M Tan, Y Cheng, X Zhong, D Yang, S Jiang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Background: Polycystic ovary syndrome (PCOS), which is often accompanied by insulin
resistance, is closely related to increased apoptosis of ovarian granulosa cells. LNK is an …

[HTML][HTML] H2S exposure induces cell death in the broiler thymus via the ROS-initiated JNK/MST1/FOXO1 pathway

Q Chi, X Hu, Z Liu, Y Han, D Tao, S Xu, S Li - … and Environmental Safety, 2021 - Elsevier
Hydrogen sulfide (H 2 S) is a common toxic gas in chicken houses that endangers the health
of poultry. Harbin has a cold climate in winter, and the conflict between heat preservation …

[HTML][HTML] FOXO3a and its regulators in prostate cancer

DE Habrowska-Górczyńska, MJ Kozieł… - International Journal of …, 2021 - mdpi.com
Forkhead box O3 (FOXO3a) is a member of a subfamily of forkhead transcription factors
involved in the basic processes within a cell, including proliferation, apoptosis, cell cycle …

Role of iron and iron‐related proteins in mesenchymal stem cells: cellular and clinical aspects

KJ Mehta - Journal of cellular physiology, 2021 - Wiley Online Library
Mesenchymal stem cells (MSCs) are located in various tissues where these cells show
niche‐dependent multilineage differentiation and secrete immunomodulatory molecules to …

[HTML][HTML] Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade

ADR Nurcahyanti, A Jap, J Lady, D Prismawan… - Biomedicine & …, 2021 - Elsevier
Diabetes mellitus (DM) is a metabolic disorder with growing global incidence, as 387 million
people were diagnosed in 2014 with an expected projection of 642 million in 2040. Several …

[HTML][HTML] Regulation of Wnt signaling by FOX transcription factors in cancer

S Koch - Cancers, 2021 - mdpi.com
Simple Summary Cancer is caused by a breakdown of cell-to-cell communication, which
results in the unrestricted expansion of cells within a tissue. In many cases, tumor growth is …