DNA repair pathways are triggered to maintain genetic stability and integrity when
mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The …

Pancreatic cancer is the fourth leading cause of cancer-related death among men and
women in the United States. A major challenge in treatment remains patients' advanced …

The distinct biology of pancreatic cancer with aggressive and early invasive tumor cells, a
tumor promoting microenvironment, late diagnosis, and high therapy resistance poses major …

Hereditary colorectal cancer (HCRC) accounts for< 5% of all colorectal cancer cases. Some
of the unique characteristics commonly encountered in HCRC cases include early age of …

Background Lynch syndrome is a rare familial cancer syndrome caused by pathogenic
variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause …

Objective Germline pathogenic variants (PVs) in the DNA mismatch repair (MMR) genes and
in the base excision repair gene MUTYH underlie hereditary colorectal cancer (CRC) and …

Simple Summary Tumor suppressor genes are critical in the control of many biological
functions. They can be classified based on their roles in proliferation, cell-cycle progression …

Patients in whom mismatch repair (MMR)-deficient cancer develops in the absence of
pathogenic variants of germline MMR genes or somatic hypermethylation of the MLH1 gene …

Background Breast cancer is the most common malignancy in women and thought to be
hereditary in 10% of patients. Recent next-generation sequencing studies have increased …

Mainstream genetic testing in routine oncology care requires implementation research to
inform intervention design. In Australia, funding is available for oncology health …