Towards population-scale long-read sequencing

W De Coster, MH Weissensteiner… - Nature Reviews …, 2021 - nature.com
Long-read sequencing technologies have now reached a level of accuracy and yield that
allows their application to variant detection at a scale of tens to thousands of samples …

Ancient DNA analysis

L Orlando, R Allaby, P Skoglund… - Nature reviews …, 2021 - nature.com
Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

Pangenomics enables genotyping of known structural variants in 5202 diverse genomes

J Sirén, J Monlong, X Chang, AM Novak, JM Eizenga… - Science, 2021 - science.org
INTRODUCTION Modern genomics depends on inexpensive short-read sequencing.
Sequenced reads up to a few hundred base pairs in length are computationally mapped to …

Pan-genome analysis of 33 genetically diverse rice accessions reveals hidden genomic variations

P Qin, H Lu, H Du, H Wang, W Chen, Z Chen, Q He… - Cell, 2021 - cell.com
Structural variations (SVs) and gene copy number variations (gCNVs) have contributed to
crop evolution, domestication, and improvement. Here, we assembled 31 high-quality …

Designing future crops: challenges and strategies for sustainable agriculture

Z Tian, JW Wang, J Li, B Han - The Plant Journal, 2021 - Wiley Online Library
Crop production is facing unprecedented challenges. Despite the fact that the food supply
has significantly increased over the past half‐century,~ 8.9 and 14.3% people are still …

Impacts of allopolyploidization and structural variation on intraspecific diversification in Brassica rapa

X Cai, L Chang, T Zhang, H Chen, L Zhang, R Lin… - Genome biology, 2021 - Springer
Background Despite the prevalence and recurrence of polyploidization in the speciation of
flowering plants, its impacts on crop intraspecific genome diversification are largely …

The need for a human pangenome reference sequence

KH Miga, T Wang - Annual Review of Genomics and Human …, 2021 - annualreviews.org
The reference human genome sequence is inarguably the most important and widely used
resource in the fields of human genetics and genomics. It has transformed the conduct of …

Plant pan-genomics comes of age

L Lei, E Goltsman, D Goodstein, GA Wu… - Annual Review of …, 2021 - annualreviews.org
A pan-genome is the nonredundant collection of genes and/or DNA sequences in a species.
Numerous studies have shown that plant pan-genomes are typically much larger than the …

Recent advances in Cannabis sativa genomics research

B Hurgobin, M Tamiru‐Oli, MT Welling… - New …, 2021 - Wiley Online Library
Cannabis (Cannabis sativa L.) is one of the oldest cultivated plants purported to have
unique medicinal properties. However, scientific research of cannabis has been restricted by …

Structural variants are a major source of gene expression differences in humans and often affect multiple nearby genes

AJ Scott, C Chiang, IM Hall - Genome research, 2021 - genome.cshlp.org
Structural variants (SVs) are an important source of human genome diversity, but their
functional effects are poorly understood. We mapped 61,668 SVs in 613 individuals from the …