Macrophage as a peripheral pain regulator
R Domoto, F Sekiguchi, M Tsubota, A Kawabata - Cells, 2021 - mdpi.com
A neuroimmune crosstalk is involved in somatic and visceral pathological pain including
inflammatory and neuropathic components. Apart from microglia essential for spinal and …
inflammatory and neuropathic components. Apart from microglia essential for spinal and …
IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice
Although sex dimorphism is increasingly recognized as an important factor in pain, female-
specific pain signaling is not well studied. Here we report that administration of IL-23 …
specific pain signaling is not well studied. Here we report that administration of IL-23 …
Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice
Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition
characterized by mechanical hypersensitivity. We previously identified microglial activation …
characterized by mechanical hypersensitivity. We previously identified microglial activation …
[HTML][HTML] Spinal macrophages resolve nociceptive hypersensitivity after peripheral injury
Peripheral nerve injury induces long-term pro-inflammatory responses in spinal cord glial
cells that facilitate neuropathic pain, but the identity of endogenous cells that resolve spinal …
cells that facilitate neuropathic pain, but the identity of endogenous cells that resolve spinal …
Dorsal root ganglia macrophages maintain osteoarthritis pain
R Raoof, CM Gil, FPJG Lafeber… - Journal of …, 2021 - Soc Neuroscience
Pain is the major debilitating symptom of osteoarthritis (OA), which is difficult to treat. In OA
patients joint tissue damage only poorly associates with pain, indicating other mechanisms …
patients joint tissue damage only poorly associates with pain, indicating other mechanisms …
Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair
Sensory neurons with cell bodies in dorsal root ganglia (DRG) represent a useful model to
study axon regeneration. Whereas regeneration and functional recovery occurs after …
study axon regeneration. Whereas regeneration and functional recovery occurs after …
The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain
The complement cascade is a key component of the innate immune system that is rapidly
recruited through a cascade of enzymatic reactions to enable the recognition and clearance …
recruited through a cascade of enzymatic reactions to enable the recognition and clearance …
Mediators of neuropathic pain; focus on spinal microglia, CSF-1, BDNF, CCL21, TNF-α, Wnt ligands, and interleukin 1β
Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …
Sensory Neuron TLR4 mediates the development of nerve-injury induced mechanical hypersensitivity in female mice
TA Szabo-Pardi, LR Barron, ME Lenert… - Brain, behavior, and …, 2021 - Elsevier
Recent studies have brought to light the necessity to discern sex-specific differences in
various pain states and different cell-types that mediate these differences. These studies …
various pain states and different cell-types that mediate these differences. These studies …
Immune regulation of pain: Friend and foe
A Kavelaars, CJ Heijnen - Science translational medicine, 2021 - science.org
The immune system and the peripheral sensory nervous system communicate through
hardwired and humoral routes using shared mediators and receptors. On the basis of …
hardwired and humoral routes using shared mediators and receptors. On the basis of …