An increase in intracellular Ca 2+ concentration ([Ca 2+] i) regulates a plethora of functions
in the cardiovascular (CV) system, including contraction in cardiomyocytes and vascular …

Plants and insect herbivores are in a relentless battle to outwit each other. Plants have
evolved various strategies to detect herbivores and mount an effective defense system …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+-mobilizing second
messenger which uniquely mobilizes Ca2+ from acidic endolysosomal organelles …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most recently discovered
Ca2+‐releasing messenger that increases the intracellular Ca2+ concentration by …

Nicotinic acid adenine dinucleotide 2'-phosphate (NAADP) is a naturally occurring
nucleotide that has been shown to be involved in the release of Ca2+ from intracellular …

Pulmonary arterial hypertension (PAH) is a form of obstructive vascular disease. Chronic
hypoxic exposure leads to excessive proliferation of pulmonary arterial smooth muscle cells …

The two-pore channels (TPCs) are voltage-gated cation channels consisting of single
polypeptides with two repeats of a canonical 6-transmembrane unit. TPCs are known to be …

Two-pore channels (TPCs) constitute a small family of ion channels within membranes of
intracellular acidic compartments, such as endosomes and lysosomes. They were shown to …

Cancer is one of the most disastrous diseases that leads to a serious threat to millions of
people's health worldwide. Cancer is distinguished by multiple common criteria, known as …

In response to pro-inflammatory challenges including pathogenic attack and tissue damage,
the endothelial cell surface is rearranged to present leukocyte-engaging cell surface …