Increasing evidence indicates that success of targeted therapies in the treatment of cancer is
context-dependent and is influenced by a complex crosstalk between signaling pathways …

Brain metastasis (BM) is the most common event in patients with lung cancer. Despite
multimodal treatments and advances in systemic therapies, development of BM remains one …

Amplification of chromosomal region 8p11–12 is a common genetic alteration that has been
implicated in the aetiology of lung squamous cell carcinoma (LUSC),–. The FGFR1 gene is …

Aberrant activation of FGFR has been linked to the pathogenesis of many tumor types.
Selective inhibition of FGFR has emerged as a promising approach for cancer treatment …

Various genetic alterations of the fibroblast growth factor receptor (FGFR) family have been
detected across a wide range of cancers. However, inhibition of FGFR signaling by kinase …

Deregulation of fibroblast growth factor receptor (FGFR) network is common in cancer due to
activating mutations, gene amplifications and chromosomal translocations. Currently …

Lung cancer is the most common cause of cancer-related deaths globally. Genetic
alterations, such as amplifications, mutations and translocations in the fibroblast growth …

Simple Summary All cells within tissues and organ systems must communicate with each
other to ensure they function in a coordinated manner. One form of communication is …

Abstract Purpose: Extramammary Paget disease (EMPD) is an uncommon skin malignancy
whose genetic alterations are poorly characterized. Previous reports identified mutations in …

Amplification of fibroblast growth factor receptor 1 (FGFR1) in non-small cell lung cancer
(NSCLC) has been considered as an actionable drug target. However, pan-FGFR tyrosine …