Reviewing the clinical implications of treating narcolepsy as an autoimmune disorder
MP Giannoccaro, R Liguori, G Plazzi… - Nature and Science of …, 2021 - Taylor & Francis
Abstract Narcolepsy type 1 (NT1) is a lifelong sleep disorder, primarily characterized
clinically by excessive daytime sleepiness and cataplexy and pathologically by the loss of …
clinically by excessive daytime sleepiness and cataplexy and pathologically by the loss of …
Narcolepsy Type I as an autoimmune disorder
BR Kornum - Handbook of Clinical Neurology, 2021 - Elsevier
Abstract Narcolepsy Type 1 (NT1) is hypothesized to be an autoimmune disease targeting
the hypocretin/orexin neurons in the lateral hypothalamus. Ample genetic and epidemiologic …
the hypocretin/orexin neurons in the lateral hypothalamus. Ample genetic and epidemiologic …
Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1
A Vuorela, TL Freitag, K Leskinen, H Pessa… - Nature …, 2021 - nature.com
Abstract Narcolepsy type 1 (NT1) is a chronic neurological disorder having a strong
association with HLA-DQB1* 0602, thereby suggesting an immunological origin. Increased …
association with HLA-DQB1* 0602, thereby suggesting an immunological origin. Increased …
HLA alleles measured from COVID-19 patient transcriptomes reveal associations with disease prognosis in a New York cohort
Background The Human Leukocyte Antigen (HLA) gene locus plays a fundamental role in
human immunity, and it is established that certain HLA alleles are disease determinants …
human immunity, and it is established that certain HLA alleles are disease determinants …
[HTML][HTML] Narcolepsy type 1 patients have lower levels of effector memory CD4+ T cells compared to their siblings when controlling for H1N1-(Pandemrix™)-vaccination …
R Viste, BA Lie, MK Viken, T Rootwelt… - Sleep Medicine, 2021 - Elsevier
Study objectives Evidence suggests a cell-mediated autoimmune pathogenesis for
narcolepsy type 1 (NT1), but it is not clear whether the disease is associated with overall …
narcolepsy type 1 (NT1), but it is not clear whether the disease is associated with overall …
The Swiss Primary Hypersomnolence and Narcolepsy Cohort study (SPHYNCS): Study protocol for a prospective, multicentre cohort observational study
A Dietmann, E Wenz, J van Der Meer… - Journal of sleep …, 2021 - Wiley Online Library
Abstract Narcolepsy type 1 (NT1) is a disorder with well‐established markers and a
suspected autoimmune aetiology. Conversely, the narcoleptic borderland (NBL) disorders …
suspected autoimmune aetiology. Conversely, the narcoleptic borderland (NBL) disorders …
Laboratory tests in pediatric sleep medicine
L Kheirandish-Gozal, D Gozal - Pediatric Sleep Medicine: Mechanisms …, 2021 - Springer
In general, use of clinical laboratory tests during evaluation of children with sleep disorders
is infrequent. Although most of the blood or cerebrospinal fluid tests related to specific sleep …
is infrequent. Although most of the blood or cerebrospinal fluid tests related to specific sleep …
[PDF][PDF] CENTRAL DISORDERS OF HYPERSOMNOLENCE: AN UPDATE
AS Triantafyllou - ADVANCES IN HEALTH AND DISEASE - researchgate.net
The central disorders of hypersomnolence are sleep disorders, characterized by excessive
daytime sleepiness due to confirmed or presumed central nervous system dysfunction. In …
daytime sleepiness due to confirmed or presumed central nervous system dysfunction. In …
Narcolepsy Type I as an autoimmune disorder
DF Swaab, RM Buijs, PJ Lucassen… - The Human …, 2021 - books.google.com
Abstract Narcolepsy Type 1 (NT1) is hypothesized to be an autoimmune disease targeting
the hypocretin/orexin neurons in the lateral hypothalamus. Ample genetic and epidemiologic …
the hypocretin/orexin neurons in the lateral hypothalamus. Ample genetic and epidemiologic …