Mechanisms of endocannabinoid control of synaptic plasticity

BL Winters, CW Vaughan - Neuropharmacology, 2021 - Elsevier
The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …

Emerging role of S100B protein implication in Parkinson's disease pathogenesis

E Angelopoulou, YN Paudel, C Piperi - Cellular and Molecular Life …, 2021 - Springer
The exact etiology of Parkinson's disease (PD) remains obscure, lacking effective diagnostic
and prognostic biomarkers. In search of novel molecular factors that may contribute to PD …

[HTML][HTML] FMR1 and Autism, an Intriguing Connection Revisited

W Fyke, M Velinov - Genes, 2021 - mdpi.com
Autism Spectrum Disorder (ASD) represents a distinct phenotype of behavioral dysfunction
that includes deficiencies in communication and stereotypic behaviors. ASD affects about …

The endocannabinoid system in the amygdala and modulation of fear

O Gunduz-Cinar - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
Posttraumatic stress disorder (PTSD) is a persistent, trauma induced psychiatric condition
characterized by lifelong complex cognitive, emotional and behavioral phenotype. Although …

Potentiation of microglial endocannabinoid signaling alleviates neuroinflammation in Alzheimer's disease

D Rapaka, VR Bitra, SR Challa, PC Adiukwu - Neuropeptides, 2021 - Elsevier
Alzheimer's disease (AD) isaprogressive neurodegenerative disorder characterized by
chronic inflammation due to the presence of neurotoxic Aβ and tau proteins. Increased …

[HTML][HTML] Receptor-Dependent and Independent Regulation of Voltage-Gated Ca2+ Channels and Ca2+-Permeable Channels by Endocannabinoids in the Brain

T Boczek, L Zylinska - International Journal of Molecular Sciences, 2021 - mdpi.com
The activity of specific populations of neurons in different brain areas makes decisions
regarding proper synaptic transmission, the ability to make adaptations in response to …

Cannabis exposure during adolescence: A uniquely sensitive period for neurobiological effects

KZ Peters, NE Zlebnik, JF Cheer - International review of neurobiology, 2021 - Elsevier
Adolescence is a crucial developmental period where neural circuits are refined and the
brain is especially vulnerable to external insults. The endocannabinoid (eCB) system …

[HTML][HTML] Multi-target effects of the cannabinoid CP55940 on familial Alzheimer's disease PSEN1 E280A cholinergic-like neurons: Role of CB 1 receptor

V Soto-Mercado, M Mendivil-Perez… - Journal of …, 2021 - content.iospress.com
Background: Alzheimer's disease (AD) is characterized by structural damage, death, and
functional disruption of cholinergic neurons (ChNs) as a result of intracellular amyloid-ß (Aß) …

[HTML][HTML] Cannabis use induces distinctive proteomic alterations in olfactory neuroepithelial cells of schizophrenia patients

M Barrera-Conde, K Ausin, M Lachén-Montes… - Journal of personalized …, 2021 - mdpi.com
A close epidemiological link has been reported between cannabis use and schizophrenia
(SCZ). However, biochemical markers in living humans related to the impact of cannabis in …

[HTML][HTML] Prolonged P300 latency in antipsychotic-free subjects with at-risk mental states who later developed schizophrenia

Y Higuchi, T Sumiyoshi, T Tateno, S Nakajima… - Journal of Personalized …, 2021 - mdpi.com
We measured P300, an event-related potential, in subjects with at-risk mental states (ARMS)
and aimed to determine whether P300 parameter can predict progression to overt …