Due to their neurodevelopmental toxicity, flame retardants (FRs) like polybrominated
diphenyl ethers are banned from the market and replaced by alternative FRs, like …

Inhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-
phenylpyridinium (MPP+) leads to the degeneration of dopaminergic neurons in man and …

Large-scale microarray studies on post-mortem brain tissues have been utilized to
investigate the complex molecular pathology of bipolar disorder. However, a major …

Motivation An important goal of concentration–response studies in toxicology is to determine
an 'alert'concentration where a critical level of the response variable is exceeded. In a …

Concurrent with the '3R'principle, the embryonic stem cell test (EST) using mouse embryonic
stem cells, developed in 2000, remains the solely accepted in vitro method for …

Objective To determine if long interspersed element‐1 (L1) retrotransposons convey risk for
idiopathic temporal lobe epilepsy (TLE). Methods Surgically resected temporal cortex from …

Proliferating cell nuclear antigen binding factor (encoded by KIAA0101/PCLAF) regulates
DNA synthesis and cell cycle progression; however, whether the level of KIAA0101 mRNA in …

This thesis describes the establishment of a human 3D in vitro model for the prediction of
teratogenic substances in the early phase of pharmaceutical compound develop-ment …

Pregnant women are exposed to an increasing number of chemicals that are potentially
hazardous to the developing embryo and fetus. This can have fatal consequences for the …

In recent times, endocrine disrupting chemicals (EDCs) have been associated with the rise
in neurodevelopmental disorders such as autism, attention deficit hyperactivity disorder …